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Toluenesulfonyl radical, widely used to block amino groups in the course of organic syntheses of drugs and other biologically active compounds.
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The 1,3Benzodioxol5 amine (1) was treated with tosyl chloride (2) in water under mild basic conditions to yield the molecule, N(1,3Benzodioxol5yl)4methylbenzenesulfonamide (3).
Keywords: 1,3Benzodioxol5amine, antibacterial activity, sulfonamides, tosyl chloride, 1H-NMR, IR, EIMS.
1,3Benzodioxol5amine (1) was subjected to nucleophilic substitution reaction with tosyl chloride (2) in water.