AstraZeneca Plc's Toprol XL, given before surgery to prevent heart complications, increases the danger of stroke or death, researchers said.
AstraZeneca's patent protection for Toprol XL expired last year, and the controlled-release drug has lost sales to generic copies.
So far this year, the company has launched a wide range of generics, including versions of AstraZeneca's Toprol XL
, Pfizer Inc.'s Lipitor and Roche Holdings Ltd.'s Boniva and GlaxoSmithKline's Requip.
For example, last year we launched metoprolol succinate 50-mg tablets, a generic equivalent of Toprol XL
[which is made by AstraZeneca PLC].
Actors presented a new prescription for one of the study drugs (Coumadin, Toprol XL, Depakote ER, Novolog MIX 70/30 insulin or Lantus insulin).
The actors attempted to purchase aspirin when they picked up Coumadin, and Sudafed PE with Toprol XL. Hidden cameras taped the results.
That total is likely to grow by the end of this year due to pending or recent patent expirations for such drugs as Ambien (for insomnia), and Norvasc and Toprol XL (both antihypertensives).
Patients using hypertension treatments, the PBM points out, could benefit from upcoming or recent patent expirations of Norvasc (amlodipine), Coreg (carvedilol) and Toprol XL (metoprolol extended release).
Of the two dozen most widely used brand name drugs in the "Rx Watchdog" report, the highest price increase (11.1%) was applied to Toprol XL
50-mg tablets, a cardioselective beta-blocker manufactured by AstraZeneca PLC.
The 10 drugs considered for the report include two generics--furosemide and hydrochlorothiazide--and eight brands: Celebrex, Fosomax, Lipitor, Norvasc, Plavix, Premarin, Toprol XL
NEW YORK -- AstraZeneca PLC has received a challenge to its patents on Toprol XL
from KV Pharmaceuticals Inc., a U.S.-based generic drug maker.