topotecan

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topotecan

A water-soluble derivative of camptothecin, obtained from the Chinese tree Camptotheca accuminata. It is a topoisomerase inhibitor which is FDA-approved for treating ovarian, cervical and small cell carcinoma of the lung.

topotecan

Hycamtin^® Oncology A topoisomerase I inhibitor used for refractory ovarian CA, small cell CA, and for colorectal and breast CAs Adverse effects Dose-limiting–never if baseline neutrophils are < 1500 cells/mm3–neutropenia, anemia, thrombocytopenia; N&V, diarrhea, alopecia Contraindications Pregnancy, breastfeeding, prior BM depression. See Topoisomerase I.

topotecan

The first of the CAMPOTHECIN analogue drugs to be approved for clinical use. Topotecan is a TOPOISOMERASE inhibitor drug used to treat cancer of the ovary and small cell cancer of the lung. (see CYTOTOXIC DRUGS). A brand name is Hycamtin.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

References in periodicals archive ?

Doctors have prescribed a two-month course of Topotecan, which is still being tested in the UK and is used by sufferers who do not respond to more conventional treatments.

Jade has new bowel cancer op; BRITAIN

Meanwhile, Jade will start a two-month course of the new wonder drug Topotecan, normally administered alongside a course of chemotherapy - a gruelling treatment that has already left Jade's body sick and weak.

'Mummy will come to my school play on Thursday won't she?' - WHAT JADE'S SON BOBBY, 5, ASKED HIS GRANNY; EXCLUSIVE JADE MUM: MY GIRL'S CANCER ANGUISH

She is also being given a new drug Topotecan, which is still being tested in the UK.

Surgery for Goody

She will begin a two-month course of Topotecan next week, which it is hoped will shrink the deadly tumours.

Cancer drug hope for Jade

During the time period of April 14-18, 1999, intravenous topotecan was administered to Maura daily for a total of 5 doses, which she received as an outpatient.

High-dose methotrexate and primary central nervous system lymphoma

Examples of topoisomerase I inhibitors are ironotecan and topotecan. Topoisomerase II inhibitors are Amsacrine and Etoposide.

Conventional treatments: chemotherapy--a medical 'solution'

Various drugs which has been used as a radio sensitizer for concurrent chemo radiation include hydroxyurea (4), mitomycin-C (5) 5-fluorouracil, Irinotecon, Topotecan, and Paclitaxel in combination with cisplatin (6-9).

Comparative efficacy of Cisplatin vs. Gemcitabine as concurrent chemotherapy for untreated locally advanced cervical cancer: a randomized trail

Researchers reported at the SGO meeting that adding thalidomide to the chemotherapy drug topotecan improved disease-free survival in recurrent ovarian cancer (as well as in primary peritoneal or fallopian tube cancers).

Special report: gynecologic cancers: cancers that affect the reproductive system are often symptomless, but awareness can lead to early detection and proper treatment

Topotecan (Hycamtin): This drug is used to treat metastatic (cancer that has spread) ovarian cancer after initial or subsequent chemotherapy has failed.

Ovarian Cancer; Treatment

A recent clinical trial, conducted by the Gynecologic Oncology Group, has demonstrated that the combination of cisplatin and topotecan is the current standard combination for the management of metastatic disease requiring chemotherapy.