tonofilament

(redirected from Tonofilaments)

ton·o·fil·a·ment

(ton'ō-fil'ă-ment),
A structural cytoplasmic protein, of a class known as intermediate filaments, bundles of which together form a tonofibril; a tonofilament is made up of a variable number of related proteins, keratins, and is found in all epithelial cells, but is particularly well developed in the epidermis.

tonofilament

[ton′ōfil′əmənt]
Etymology: Gk, tonos, stretching
a proteinaceous fiber found in epithelial cells. Bundles of tonofilaments form a tonofibril, which has a supporting function.

ton·o·fil·a·ment

(ton'ō-fil'ă-mĕnt)
A structural cytoplasmic protein, bundles of which together form a tonofibril; tonofilaments are made up of a variable number of related proteins, keratins, and are found in all epithelial cells.

tonofilament

(ton″ō-fil′ă-mĕnt) [ tono- + filament]
A bundle of intermediate filaments within a cell. They bind the pieces of the cytoskeleton to each other and to the cell membrane.
References in periodicals archive ?
Apoptotic bodies rich in tonofilaments were not found.
In the few studies where electron microscopy was used, some of the stromal cells had epithelial features, such as tonofilaments and intercellular junctions, similar to squamous epithelial cells.
Composition of amyloid in various types of amyloidosis * Type Subtype Composition of amyloid Localized Nodular Immunoglobulin light chains produced by cutaneous local plasma cell infiltration Lichen Keratinocyte tonofilaments Macular Keratinocyte tonofilaments Systemic Primary Immunoglobulin light chains resulting from plasma cell dyscrasia Secondary An apoprotein complex resulting from chronic inflammation; no cutaneous lesions are seen * From references 7, 8.
The finding of epithelial elements, mature desmosomes, and tonofilaments in the original neoplasm secured the diagnosis of spindle-cell squamous carcinoma.
Ultrastructurally, (3-5) the main cells are characterized by cytoplasmic tonofilaments and desmosome-like structures, while the neuroendocrine cells showed electron-dense secretory granules.
Cellular junctional complexes, including desmosomes and tonofilaments, are scanty, and lumina (intercellular and intracellular) are usually absent.
In the cytoplasm, undulating filaments that were located close to the nucleus were most consistent with tonofilaments.
Desmosomes, tonofilaments, and melanosomes were not identified in the tumor It was postulated that such rare aggressive behavior of atypical fibroxanthomas might be due to an altered immune response as a result of chronic lymphocytic leukemia.
1] In addition, SCEVs express both cytokeratin and vimentin and ultrastructurally show tonofilaments not only within recognizable aggregates of squamous cells but also within the spindle cell population.
No microvilli, tonofilaments, or desmosomes were present.