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Toluenesulfonyl radical, widely used to block amino groups in the course of organic syntheses of drugs and other biologically active compounds.
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5 mmol) in DMAc, carboxylic acid activating reagent p- toluenesulfonyl chloride (3.
p- Toluenesulfonyl chloride (Tos-Cl) is one of the most famous COOH activator which is widely used under homogenous esterification reaction conditions.
p- toluenesulfonyl chloride is an efficient and widely used reagent for such conversions and better than the conventional reagents like acid chlorides and acid anhydrides [17, 18] which may impart toxic side products and impurities in prodrugs.