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Any of a class of proteins that are located within membranes, often on the cell surface, and are an important part of the innate immune system. Toll-like receptors recognize and bind to pathogens or to fragments resulting from cell damage and then activate biochemical pathways that generate an immune response.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
toll-like receptorAbbreviation: TLR
Any of several receptors on macrophages and other immune and endothelial cells that reacts with pathogen components such as bacterial peptidoglycan or lipopolysaccharide. Activation of a receptor stimulates release of cytokines and other chemical signals that are part of innate immunity.
See also: receptor
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