Also found in: Dictionary, Thesaurus, Wikipedia.
Related to Tolectin: tolmetin sodium
trademark for a preparation of tolmetin sodium; a nonsteroidal antiinflammatory drug.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
Pregnancy Category: UK
Management of inflammatory disorders including:
- Rheumatoid arthritis,
- Juvenile rheumatoid arthritis,
Inhibits prostaglandin synthesis.
Suppression of pain and inflammation.
Absorption: Well absorbed from the GI tract following oral administration.
Protein Binding: >99%.
Metabolism and Excretion: Mostly metabolized by the liver; 20% excreted unchanged by the kidneys.
Half-life: 1 hr.
Time/action profile (anti-inflammatory effects)
|PO||within 7 days||1–2 wk||unknown|
Contraindicated in: Hypersensitivity; Cross-sensitivity may exist with other NSAIDs, including aspirin; Active GI bleeding or ulcer disease; Perioperative pain from coronary artery bypass graft (CABG) surgery.
Use Cautiously in: Cardiovascular disease or risk factors for cardiovascular disease (may ↑ risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, especially with prolonged use); History of ulcer disease; Severe hepatic or renal impairment (dosage ↓ recommended); Geriatric: ↑ risk of GI bleeding; Obstetric / Lactation: Safety not established; avoid use during 2nd and 3rd trimesters.
Adverse Reactions/Side Effects
Central nervous system
- dizziness (most frequent)
- headache (most frequent)
- mental depression
- sleep disturbances
Ear, Eye, Nose, Throat
- visual disturbances
- edema (most frequent)
- drug-induced hepatitis (life-threatening)
- GI bleeding (life-threatening)
- diarrhea (most frequent)
- discomfort (most frequent)
- dyspepsia (most frequent)
- nausea (most frequent)
- vomiting (most frequent)
- renal failure
- exfoliative dermatitis (life-threatening)
- stevens-johnson syndrome (life-threatening)
- toxic epidermal necrolysis (life-threatening)
- rash (most frequent)
- prolonged bleeding time
- muscle weakness
- allergic reactions including anaphylaxis (life-threatening)
Drug-Drug interaction↑ risk of bleeding with warfarin, heparin,, cefoperazone, cefotetan, valproates, thrombolytic agents, clopidogrel, ticlopidine, abciximab, tirofiban, or eptifibatide.↑ GI side effects with aspirin, corticosteroids, and other NSAIDs.May ↓ response to antihypertensives or diuretics.May ↑levels and risk of toxicity from lithium.May ↑ risk of hematologic toxicity from antineoplastics or radiation therapy.↑ risk of adverse renal effects with gold compounds, cyclosporine, or chronic use of acetaminophen.May ↑ risk of hypoglycemia frominsulin or oral hypoglycemic agents.↑ anticoagulant effect and bleeding risk with arnica, chamomile, clove, dong quai, feverfew, garlic, ginger, ginkgo, Panax ginseng, and others.
Oral (Adults) 400 mg 3 times daily initially, followed by maintenance dose of 600–1800 mg/day in 3–4 divided doses (not to exceed 2000 mg/day).
Oral (Children >2 yr) 20 mg/kg/day in 3–4 divided doses initially, followed by maintenance dose of 15–30 mg/kg/day in 3–4 divided doses.
Availability (generic available)
Tablets: 200 mg, 600 mg
Capsules: 400 mg
- Patients who have asthma, aspirin-induced allergy, and nasal polyps are at increased risk for developing hypersensitivity reactions. Monitor for rhinitis, asthma, and urticaria.
- Assess patient for skin rash frequently during therapy. Discontinue tolmetin at first sign of rash; may be life-threatening. Stevens-Johnson syndrome or toxic epidermal necrolysis may develop. Treat symptomatically; may recur once treatment is stopped.
- Assess pain and range of motion prior to and weekly during therapy.
- Lab Test Considerations: Evaluate BUN, serum creatinine, CBC, and liver function periodically in patients receiving prolonged therapy.
- Serum potassium, BUN, AST, and ALT may show ↑ levels.
- Hemoglobin and hematocrit may be ↓. Bleeding time may be prolonged for up to 2 days after discontinuation.
- May cause false-positive results for urinary protein.
Potential Nursing DiagnosesAcute pain (Indications)
Impaired physical mobility (Indications)
- Administration in higher than recommended doses does not provide increased effectiveness but may cause increased side effects. Use lowest effective dose for shortest period of time.
- Oral: May be administered with food, milk, or antacids to decrease GI irritation. Tablets may be crushed and capsules opened and mixed with fluids or food.
- Advise patient to take tolmentin with a full glass of water and to remain in an upright position for 15–30 min after administration.
- Instruct patient to take medication as directed. Take missed doses as soon as remembered but not if almost time for the next dose. Do not double doses.
- May cause drowsiness or dizziness. Advise patient to avoid driving or other activities requiring alertness until response to medication is known.
- Caution patient to avoid the concurrent use of alcohol, aspirin, NSAIDs, acetaminophen, or other OTC or herbal products without consulting health care professional.
- Advise patient to use sunscreen and protective clothing to prevent photosensitivity reactions.
- Advise patient to inform health care professional of medication regimen prior to treatment or surgery.
- Advise patient to consult health care professional if rash, itching, visual disturbances, tinnitus, weight gain, edema, black stools, persistent headache, or influenza-like syndrome (chills, fever, muscle aches, pain) occurs.
- Decrease in pain.
- Improved joint mobility. Partial arthritic relief is usually seen within 7 days, but maximum effectiveness may require 1–2 wk of continuous therapy. Patients who do not respond to one NSAID may respond to another.
Drug Guide, © 2015 Farlex and Partners
Tolectin®Tolmetin, see there.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.