TRAF6

(redirected from Tnf receptor-associated factor 6)

TRAF6

A gene on chromosome 11p12 that encodes an E3 ubiquitin ligase which, together with UBE2N and UBE2V1, synthesises Lys-63-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. It also ubiquitinates a free/unanchored polyubiquitin chain, leading to MAP3K7 activation, and activates NF-kappaB and JUN. It may be essential for forming functional osteoclasts and is thought to play a role in dendritic cell maturation and/or activation. It represses c-Myb-mediated transactivation of B cells. It acts as an adapter protein for signal transduction by TNF receptor, as well as IL-1 and IL-17 receptors. It is expressed in the heart, brain, placenta, lungs, liver, skeletal muscle, kidneys and pancreas.
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In this context, IRAK4 phosphorylates IRAK1 activating it, which permits its interaction with the TNF receptor-associated factor 6 (TRAF6) in the cytoplasm causing its activation after its phosphorylation [14].
Interaction between RANK and RANKL leads to the recruitment of TNF receptor-associated factor 6 (TRAF6) and the subsequent activation of several downstream signalling pathways including nuclear factor-kB (NF-[kappa]B) as well as the p38 mitogen-activated protein kinase (MAPK), c-Jun-N-terminal kinase QNK), extracellular signal-regulated kinase (ERIC) and PI3K/AKT signalling pathways (Wei et al.
RANK recruits the adapter molecule, TNF receptor-associated factor 6 (TRAF6), which activates NF-[kappa]B pathways (Boyle et al.
The research at the University of Louisville describes the role of TNF receptor-associated factor 6 (TRAF6), an adaptor protein and E3 ubiquitin ligase, in ensuring the vitality of stem cells that regenerate muscle tissue.
Bishop, "Characterization of the roles of TNF receptor-associated factor 6 in CD40-mediated B lymphocyte effector functions" 7^e Journal of Immunology, vol.