Tn syndrome

Tn syndrome

Hematology A chronic myelodysplasia associated with polyagglutination of RBCs Clinical Severe thrombocytopenia, hemolytic anemia, leukopenia; RBCs and platelets lack T-transferase–UDPGal:GalNAc-β-3-D-galactosyltransferase, resulting in inability to express GPIb glycoprotein and cryptantigen Tn, which reacts with naturally-occurring antibodies, causing global hemolysis and clotting
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.