PRKAR1A(redirected from Tissue-Specific Extinguisher 1)
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PRKAR1AA gene on chromosome 17q23-q24 that encodes one of the regulatory subunits that comprise cAMP-dependent protein kinase. This enzyme transduces activating signals by phosphorylating different target proteins. PRKAR1A downregulates expression of liver genes in hepatoma/fibroblast hybrids.
PRKAR1A mutations cause Carney complex; it can fuse to the RET proto-oncogene by gene rearrangement and form PTC2, a thyroid tumour-specific chimeric oncogene.