kallikrein

(redirected from Tissue kallikreins)
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Related to Tissue kallikreins: kallikrein serine protease 1

kallikrein

 [kal″ĭ-kre´in]
any of several serine endopeptidases that cleave kininogens to form kinins.
plasma kallikrein a hydrolytic enzyme of the plasma that cleaves HMW (high-molecular-weight) kininogen to produce bradykinin. It also activates several blood coagulation factors and plasminogen. It is formed from prekallikrein by activated coagulation factor XII.
tissue kallikrein a hydrolytic enzyme that cleaves LMW kininogen to produce kallidin. It and closely related forms are found in tissues and various glandular secretions such as lymph, pancreatic juice, urine, and saliva.

kal·li·kre·in

(kal'i-krē'in),
A group of enzymes (for example, plasma, tissue, pancreatic, urinary, or submandibular kallikrein) that converts kininogen by proteolysis to bradykinin or kallidin. Trypsin and plasmin can also effect the conversion. Plasma kallikrein activates factor XII and acts on kininogen. Tissue kallikrein is a serine endopeptidase that can generate kallidin from kininogen.

kallikrein

/kal·li·kre·in/ (kal″ĭ-kre´in) any of several serine proteinases that cleave kininogens to form kinins.
plasma kallikrein  a plasma hydrolase that cleaves HMW kininogen to produce bradykinin and also activates blood coagulation factors XII and VII and plasminogen.
tissue kallikrein  a hydrolase of tissues and various glandular secretions that cleaves LMW kininogen to form kallidin.

KLK4

A gene on chromosome 19q13.41 that encodes a serine protease expressed in the prostate.

Molecular pathology
Mutations of KLK4 cause amelogenesis imperfecta hypomaturation type 2A1.

kal·li·kre·in

(kal'i-krē'in)
A group of enzymes (e.g., plasma, tissue, pancreatic, urinary, submandibular kallikrein) that can convert kininogen by proteolysis to bradykinin or kallidin; trypsin and plasmin can also effect the conversion; plasma kallikrein activates the Hageman factor and acts on kininogen. Tissue kallikrein is a serine endopeptidase that can generate kallidin from kininogen.
Synonym(s): kininogenase, kininogenin.

Kallikrein

Any of a group of compounds in the body known as serine endopeptidases that help to break down proteins into smaller units. Prostate-specific antigen belongs to this group of chemicals. A recently discovered kallikrein may be useful as a biomarker for ovarian cancer.
Mentioned in: Ovarian Cancer

kal·li·kre·in

(kal'i-krē'in)
A group of enzymes that can convert kininogen by proteolysis to bradykinin or kallidin.

kallikrein

any of a group of proteolytic enzymes present in various glands, lymph, urine, blood plasma, etc., or produced directly from mast cells or basophils, or indirectly from activated platelets. The major action of kallikreins is the liberation of kinins from α-2-globulins (kininogens), and they hence have vasodilator and whealing actions.

kallikrein-kinin system
the enzyme system responsible for capillary permeability and smooth muscle contraction.
References in periodicals archive ?
The association with age, human tissue kallikreins 6 and 10 and hemostatic markers for survival outcome from epithelial ovarian cancer.
Transcriptional upregulation of human tissue kallikrein 6 in ovarian cancer: clinical and mechanistic aspects.
The kallikrein world: an update on the human tissue kallikreins.
The human tissue kallikrein (KLK) [3] family consists of 15 genes located in tandem on chromosome 19q13.
Further evidence has shown that human tissue kallikrein 7 (KLK7) [6] mRNA is significantly up-regulated in ovarian tumors (20, 21).
5] Nonstandard abbreviations: FIGO, Federation Internationale des Gynaecologistes et Obstetristes; hK, human tissue kallikrein protein; PFS, progression-free survival; OS, overall survival; HR, hazard ratio.
Expanded human tissue kallikrein family: a novel panel of cancer biomarkers.
The human tissue kallikrein family includes 15 genes (KLK1 to KLK15) [6] clustered in tandem on chromosome 19813.
Human stratum corneum chymotryptic enzyme (hK7; HSCCE) (9,10), one of the few tissue kallikreins for which a physiologic function has been proposed, catalyzes the degradation of intercellular cohesive structures in the outermost layer of the skin and contributes to the cell shedding process at the skin surface (11).
Serpin-derived peptide substrates for investigating the substrate specificity of human tissue kallikreins hK1 and hK2.
Expression and localization of tissue kallikrein mRNAs in human epidermis and appendages.