The Company's portfolio of approved and marketed brands includes: Xydalba (dalbavancin hydrochloride), for the treatment of acute bacterial skin and skin structure infections (ABSSSI); Zevtera/Mabelio (ceftobiprole medocaril sodium), a cephalosporin antibiotic for the treatment of community- and hospital-acquired pneumonia (CAP, HAP); Brinavess (vernakalant IV) for the rapid conversion of recent onset atrial fibrillation to sinus rhythm; Aggrastat (tirofiban
hydrochloride) for the reduction of thrombotic cardiovascular events in patients with acute coronary syndrome.
Glycoprotein IIb/IIIa inhibitor (Tirofiban
) was administered to the patients in the catheterization laboratory at the operator's discretion.
The company reported net revenue from the sale of AGGRASTAT (tirofiban
hydrochloride) at USD4.8m in the quarter ended 31 March 2019, compared to USD6.1m for the same period in 2018.
(8) The CAP approach is to have laboratories collect normal citrated anticoagulated whole blood that is added to challenge tubes containing either saline, to simulate a normal sample, or tirofiban
, a GPIIbIIIa (integrin [[alpha].sub.IIb][[beta].sub.3]) inhibitor that blocks platelet aggregation, to simulate an abnormal sample, followed by platelet function testing.
Resume therapy after 8 h * Tirofiban
(Aggrastat) Withhold 4 h.
Invasive versus conservative strategies in unstable angina and non-Q-wave myocardial infarction following treatment with tirofiban
: rationale and study design of the international TACTICS-TIMI 18 Trial.
heparin with or without tirofiban
during primary percutaneous coronary intervention in acute myocardial infarction: The BRIGHT randomized clinical trial.
Comparison of angioplasty with infusion of tirofiban
or abciximab and with implantation of sirolimus-eluting or uncoated stents for acute myocardial infarction: the MULTISTRATEGY randomized trial.
Drugs targeting arterial thrombi include the antiplatelet drugs (aspirin, clopidogrel, abciximab, eptifibatide and tirofiban
) and the fibrinolytics (streptokinase and alteplase).
"I hope I will come back for a joint research projects." The scientist said he was looking for Arabian partners, institutions or universities "so that we can discover these hidden gems." "For example, Tirofiban
, a lifesaving drug used for heart patients, comes from an Arabian snake, Echis carinatus, or "efa." "Most of Arabia's venomous creatures -- snakes, scorpions, spiders and many marine creatures -- remain unexplored by scientists.
Serruys et al., "Prediction of 1-year clinical outcomes using the SYNTAX score in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: a substudy of the STRATEGY (Single High-Dose Bolus Tirofiban
and Sirolimus-Eluting Stent Versus Abciximab and Bare-Metal Stent in Acute Myocardial Infarction) and MULTISTRATEGY (Multicenter Evaluation of Single High-Dose Bolus Tirofiban
Versus Abciximab With Sirolimus-Eluting Stent or Bare-Metal Stent in Acute Myocardial Infarction Study) trials," JACC Cardiovascular Interventions, vol.