Commercial launch for THIOLA EC (tiopronin
) is underway following approval by U.S.
is a medication used to aid in preventing the formation of cystine kidney stones.
Cadmium telluride quantum dots as pH-sensitive probes for tiopronin
Those studies demonstrated the protective effects of N-acetylcysteine , D-methionine , L-methionine , ebselen and allopurinol , tiopronin
, vitamin E,  and steroids [23, 24] against cisplatin ototoxicity.
The numerous otoprotective agents utilized in clinical and animal studies include Amifostine, D-or L-Methionine, methylthiobenzoic acid, lipoic acid, tiopronin
, glutathione ester, sodium thiosulfate , Melatonin , Vitamin E , N-acetylcysteine , Dexamethasone , and Resveratrol .
Most of the latter patients received conventional liver-protecting treatment, for instance, polyene phosphatidylcholine, tiopronin
on Hartley albino guinea pigs, found beneficial effects of alpha-tocopherol and tiopronin
on cisplatin-induced ototoxicity.
Pharmaceutical company Retrophin (NasdaqGM:RTRX) revealed on Thursday the launch of an agreement for licensing the US marketing rights of its Thiola (tiopronin
) for an undisclosed value.
One batch with hydrogen tetrachloroaurate(III) trihydrate (1 equiv) and N-(2-mercaptopropionyl)glycine (tiopronin
) (5.5 equiv) was codissolved in 35mL of 6:1 methanol/acetic acid, resulting in a ruby red solution.
Alternatively, gold nanoparticles can be directly synthesized in the presence of thiolated ligands, including chemically functional species such as tiopronin
, glutathione, and coenzyme A [29-31], to circumvent the need for ligand exchange.
(Thiola), which reduces the amount of cystine in the urine.