tioconazole


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tioconazole

 [ti″o-kon´ah-zōl]
an imidazole derivative used as a topical antifungal agent, applied intravaginally in treatment of vulvovaginal candidiasis.

tioconazole

Vagistat® Gynecology An oral agent for vaginal candidiasis

tioconazole

An IMIDAZOLE antifungal drug used externally to treat nail infections with TINEA and CANDIDA ALBICANS fungi. A brand name is Trosyl.
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[5] Imidazole group of antifungals are commonly used in vaginal candidiasis which includes clotrimazole, fluconazole, isoconazole, oxiconazole, omoconazole and tioconazole. [6] These drugs have limited systemic absorption when used in larger doses and not effective in recurrent chronic vaginal candidiasis.
The mycological literature devotes much attention to the issue of fungal resistance and reduced susceptibility to commonly used antifungal drugs [8-13], and it emphasizes that the process is still in progress, especially for azole chemotherapeutics (ketoconazole, tioconazole, miconazole, fluconazole, itraconazole).
** Tioconazole 6.5% ointment (OTC): 5 g intravaginally in a single application
Antifungal agents are either polyenes (nystatin and am-photericin B) or azoles which are classified into: imidazoles (clotrimazole, econazole, fenticonazole, isoconazole, ketocon-azole, miconazole, sulconazole, tioconazole); and triazoles (fluconazole, itraconazole).
Gentamycin (10[micro]g/ml) and Tioconazole (0.7mg/ml) were included as standard reference drugs in the study.
In Switzerland, three triazoles (terconazole, itraconazole, fluconazole) and eight imidazoles (clotrimazole, miconazole, econazole, ketoconazole, tioconazole, isoconazole, oxiconazole, and fenticonazole) are in use (Documed AG 2002).
20 Tioconazole (5 [micro]g/ml) -- -- -- organisms zone of inhibition (mm) Extract Sa Bs Ca Hexane (200 mg/ml) 9 11 24 Dichloromethane (200 mg/ml) -- 11 12 Methanol (200 mg/ml) -- -- -- Carvacrol (4 [micro]l/disk) 27 26 38 Ampicillin ([micro]g/ml) 12 10 -- Tioconazole (5 [micro]g/ml) -- -- 16 -- no activity; n.t.
Uncomplicated candidal vaginitis responds to any of numerous intravaginal preparations of clotrimazole, miconazole, tioconazole, and butaconazole available over the counter.
Uncomplicated candidal vaginitis responds to any number of intravaginal preparations of clotrimazole, miconazole, tioconazole, and butaconazole available over the counter.
Table - 4 List of pharmaceutical products, imported without violating patent rights Name of products Acidum pipemidig Atenolol Albendazol Amineptina Aciclovir Acid clavulanic Astemizole Aztreonam Bacampicillin Budesonide Bitolterol mesylate Bromcriptine masylate Bifonazol Cyclosporin Cefadroxil monohydrat Cefotaxime sodium Cyclopirox olamine Cytarabine Hcl Cetraxate Hcl Cefsulodin sodium Cefoperazone Domperidon Estazolam Fentiazac Isoconazol Ipratropium bromide Ifosfamide Ketoconazol Labetalol Hcl Minoxidil Miconazol Metroprolol tartrat Metrizamide Mianserin Hcl Midazolam malfate Metilmicin SO4 Nadolol Nicardipine Hcl Nor floxacin Oxatomide Piroxicam Praziquantel Procaterol Hcl Prazosin Hcl Sisomicin sulfat Sulprostone Tiemonium metil SO4 Tioconazole Vindesine SO4 Vecuronium bromide