Tingible Body Macrophage

A term of art for an ordinary macrophage in a reactive germinal center. Tingible body macrophages are characterised by sparkling intracellular material
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Normal follicles have tingible body macrophages, but neoplastic ones of grade 1 or grade 2 lack macrophages and show a monotonous, nonpolarized appearance composed predominantly of centrocytes.
The monoclonal antibody HAM56 labels bloodborne tissue macrophages such as hepatic Kupffer cells and pulmonary alveolar macrophages in addition to tingible body macrophages and interdigitating macrophages of lymph nodes.