Tingible Body Macrophage

A term of art for an ordinary macrophage in a reactive germinal center. Tingible body macrophages are characterised by sparkling intracellular material
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FIGURE 2 & 2A: Shows reactive lymphadenitis with tingible body macrophage (100x); 2B-Shows suppurative lymphadenopathy with plenty of acute inflammatory cells and lymphocytes (1000x).
Reactive lymphadenitis was second most common finding with 13(26%) cases showing predominantly small lymphocytes, transforming lymphocytes, centrocytes, centroblasts, tingible body macrophages and few histiocytes.
Reactive lymphadenitis was second most common finding 14(28%) showing small lymphocytes, transforming lymphocytes, centrocytes, centroblasts, tingible body macrophages and few histiocytes.
The residual lymph node showed reactive germinal centers and tingible body macrophages, but no hemophagocytosis (Figure 1).
Secondary follicles form when primary follicles react to antigen stimulation and are characterized by a peripheral mantle zone of small mature B cells surrounding a central germinal center made up of antigen-selected centroblasts and centrocytes that segregate into polarized dark and light zones, respectively, with admixed tingible body macrophages and follicular dendritic cells (Figure 1, C).
Reactive follicles may show variability in size and shape but typically exhibit polarized germinal centers that are made up of centroblasts and centrocytes with admixed tingible body macrophages and small mature lymphocytes, which are cuffed by well-formed and defined mantle zone (Figure 2, B and C).
5) Malignant follicles show a loss of polarity with a haphazard distribution of centrocytes and centroblasts as well as reduced numbers of tingible body macrophages (Figure 3, B).
In addition, tingible body macrophages contain "ingested nuclear debris, which represents lymphocytes that have been selected to be destroyed in reactive follicles.
Smears from fine needle aspiration of the mass lesion predominantly showed small and large lymphocytes, tingible body macrophages admixed with fibrotic strands in haemorrhagic background (Figure 2 A and B).
The monoclonal antibody HAM56 labels bloodborne tissue macrophages such as hepatic Kupffer cells and pulmonary alveolar macrophages in addition to tingible body macrophages and interdigitating macrophages of lymph nodes.