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(tol-naff-tate) ,

Lamisil AF

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Therapeutic: antifungals
Pregnancy Category: C


Treatment of a variety of cutaneous fungal infections, including tinea pedis (athlete’s foot), tinea cruris (jock itch), and tinea corporis (ringworm).


Distorts the hyphae and stunts mycelial growth in fungi.

Therapeutic effects

Decrease in symptoms of fungal infection.


Absorption: Absorption through intact skin is minimal.
Distribution: Distribution after topical administration is primarily local.
Metabolism and Excretion: Systemic metabolism and excretion not known following local application.
Half-life: Not applicable.

Time/action profile

Topical24–72 hrunknownunknown


Contraindicated in: Hypersensitivity to active ingredients, additives, preservatives, or bases; Some products contain alcohol and should be avoided in patients with known intolerance.
Use Cautiously in: Nail and scalp infections (may require additional systemic therapy); Obstetric / Lactation: Safety not established.

Adverse Reactions/Side Effects


  • burning
  • itching
  • local hypersensitivity reactions
  • redness
  • stinging


Drug-Drug interaction

Not known.


Topical (Adults and Children ≥2 yr) Apply twice daily for up to 2 wk for tinea cruris and for up to 4 wk for tinea pedis or tinea corporis.

Availability (generic available)

Cream: 1%OTC
Powder: 1%OTC
Solution: 1%OTC
Spray liquid: 1%OTC
Spray powder: 1%OTC

Nursing implications

Nursing assessment

  • Inspect involved areas of skin and mucous membranes before and frequently during therapy. Increased skin irritation may indicate need to discontinue medication.

Potential Nursing Diagnoses

Risk for impaired skin integrity (Indications)
Risk for infection (Indications)


  • Consult health care professional for proper cleansing technique before applying medication.
  • Topical: Apply small amount to cover affected area completely. Avoid the use of occlusive wrappings or dressings unless directed by health care professional.

Patient/Family Teaching

  • Instruct patient to apply medication as directed for full course of therapy, even if feeling better. Emphasize the importance of avoiding the eyes.
  • Caution patient that some products may stain fabric, skin, or hair. Check label information. Fabrics stained from cream can usually be cleaned by handwashing with soap and warm water.
  • Patients with athlete’s foot should be taught to wear well-fitting, ventilated shoes, to wash affected areas thoroughly, and to change shoes and socks at least once a day.
  • Advise patient to report increased skin irritation or lack of response to therapy to health care professional.

Evaluation/Desired Outcomes

  • Decrease in skin irritation and resolution of infection. Early relief of symptoms may be seen in 2–3 days. For tinea cruris and tinea corporis, 2 wk are needed, and for tinea pedis, therapeutic response may take 4 wk. Recurrent fungal infections may be a sign of systemic illness.


a trademark for an antifungal (tolnaftate).
References in periodicals archive ?
commands second, third and fourth place with its Lotrimin AF, Tinactin and Lotrimin Ultra brands, respectively.
Major Products: Foot care--Lotrimin AF and Tinactin anti-fungals; Sun care--Coppertone and Bain de Soleil.
Besides the Lotramin line, Schering-Plough markets the best-selling brands Tinactin and Dr.
markets Lotrimin AF, Lotrimin Ultra, Tinactin and Dr.
Lotrimin AF and Tinactin antifungal products maintained their No.
Schering-Plough has responded with its Tinactin athlete's foot medications, which seeks to prevent athlete's foot, instead of alleviating its discomfort.
Its Lotrimin AF and Tinactin lines ranked first and third among the top-selling brands, with sales of $50 million and $44.
Category leader Schering-Plough HealthCare Products offers the Tinactin athlete's foot medication as a sports wipe and a spray.
which dominates the segment with its Lotrimin AF and Tinactin athlete's foot medications, offers its Tinactin Sports Wipes medicated pads as well as its Tinactin pump spray.