Also found in: Dictionary.
Related to Tigan: timolol, Phenergan


trademark for preparations of trimethobenzamide hydrochloride, an antiemetic.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

trimethobenzamide hydrochloride


Pharmacologic class: Anticholinergic

Therapeutic class: Antiemetic

Pregnancy risk category C


Unclear. Thought to block dopamine receptors and emetic impulses in chemoreceptor trigger zone, preventing nausea and vomiting.


Capsules: 300 mg

Injection: 100 mg/ml in 2-ml ampules and prefilled syringes and in 20-ml vials

Indications and dosages

Nausea and vomiting

Adults: 300 mg P.O. three to four times daily or 200 mg I.M. three to four times daily

Dosage adjustment

• Renal impairment


• Hypersensitivity to drug

• Parenteral form in children


Use cautiously in:

• renal impairment, arrhythmias, encephalitis, gastroenteritis, dehydration, electrolyte imbalances

• concurrent alcohol use

• elderly or debilitated patients

• pregnant or breastfeeding patients

• children with known or suspected viral illnesses.


• In I.M. use, inject deep into upper outer quadrant of gluteus maximus.

• Withhold drug in children with signs or symptoms of Reye's syndrome.

Adverse reactions

CNS: drowsiness, dizziness, headache, depression, disorientation, parkinsonian symptoms, coma, seizures

CV: hypotension

EENT: blurred vision

Hematologic: blood dyscrasias

Hepatic: jaundice

Musculoskeletal: muscle cramps, opisthotonos

Skin: rash, urticaria, flushing

Other: pain and stinging at I.M. injection site, hypersensitivity reaction


Drug-drug. Antidepressants, antihistamines, CNS depressants, opioids, sedative-hypnotics: additive CNS depression

Drug-behaviors. Alcohol use: additive CNS depression

Patient monitoring

• Monitor neurologic status, especially for parkinsonian symptoms and other serious adverse reactions.

• Assess CBC and liver function tests. Watch for blood dyscrasias and jaundice.

• Evaluate injection site for pain and stinging.

• Closely monitor patient's nutritional and hydration status. Report continuing nausea.

Patient teaching

• Advise patient to take as needed for nausea and vomiting, but only as prescribed.

• Tell patient to contact prescriber promptly if nausea persists despite therapy.

• Instruct patient to minimize nausea and vomiting by eating small, frequent servings of healthy food and drinking plenty of fluids.

• Advise patient to avoid alcohol.

• Caution patient to avoid driving and other hazardous activities until drug effects are known.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and behaviors mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved


(trye-meth-oh-ben-za-mide) ,


(trade name)


Therapeutic: antiemetics
Pharmacologic: anticholinergics
Pregnancy Category: C


Mild to moderate nausea and vomiting.


Inhibits emetic stimulation of the chemoreceptor trigger zone in the medulla.

Therapeutic effects

Decreased nausea and vomiting.


Absorption: Complete absorption following oral and IM administration.
Distribution: Unknown.
Metabolism and Excretion: Metabolized by the liver; 30–50% excreted unchanged in urine.
Half-life: 7–9 hr.

Time/action profile (antiemetic effect)

PO10–40 minunknown3–4 hr
IM15–35 minunknown2–3 hr


Contraindicated in: Hypersensitivity.
Use Cautiously in: Pediatric: Children; Geriatric: Appears on Beers list. Potential for extrapyramidal side effects may outweigh potential benefit; Obstetric / Lactation: Safety not established.

Adverse Reactions/Side Effects

Central nervous system

  • coma (life-threatening)
  • seizures (life-threatening)
  • drowsiness (most frequent)
  • depression
  • extrapyramidal reactions


  • hypotension (most frequent)


  • diarrhea
  • hepatitis


  • rashes


  • blood dyscrasias


  • pain (most frequent)
  • burning at IM injection site
  • redness at IM injection site
  • stinging at IM injection site


Drug-Drug interaction

↑ CNS depression with other CNS depressants, including alcohol, antidepressants, antihistamines, opioid analgesics, and sedative/hypnotics.


Oral (Adults) 300 mg 3–4 times daily.
Intramuscular (Adults) 200 mg 3–4 times daily as needed.

Renal Impairment

(Adults) CCr ≤70 mL/min—↓ dose or ↑ dosing interval.

Availability (generic available)

Capsules: 300 mg
Injection: 100 mg/mL

Nursing implications

Nursing assessment

  • Assess patient for nausea and vomiting prior to and 30–60 min following administration.
  • Assess BP for hypotension following parenteral administration.

Potential Nursing Diagnoses

Risk for deficient fluid volume (Indications)
Risk for injury (Side Effects)


  • Oral: Capsules can be opened and contents mixed with food or fluids for patients with difficulty swallowing.
  • Intramuscular: Inject deep into well-developed muscle mass to minimize tissue irritation.
    • Trimethobenzamide is not receommended for IV use.

Patient/Family Teaching

  • Instruct patient to take medication as directed. Take missed doses as soon as remembered unless almost time for next dose; do not double doses.
  • Advise patient to make position changes slowly to minimize orthostatic hypotension following parenteral doses.
  • May cause drowsiness. Caution patient to avoid driving or other activities requiring alertness until response to medication is known.
  • Caution patient to avoid taking alcohol or other CNS depressants concurrently with this medication.
  • Instruct patient to notify health care professional promptly if sore throat, fever, unusual weakness or tiredness, tremors, or yellowing of the skin and eyes occurs.

Evaluation/Desired Outcomes

  • Prevention and relief of nausea and vomiting.
Drug Guide, © 2015 Farlex and Partners
References in periodicals archive ?
Sundarapandian, "Output regulation of the Tigan system," International Journal on Computer Science & Engineering, vol.
The fate of the Tigan project was not immediately clear after Orascom withdrew from managing the development.
"Intrebat cu cine semanam noi, comunistii, un tigan raspunde:
Mayala representatives, Aubrey Tigan and Lorna Hudson OAM said; "We have been involved with Pluton people now for over 3 years and have built a friendship based on mutual trust and respect.
Cependant, afin d'assurer un certain regard critique, nous combinons a ces sources officielles accessibles en ligne des articles scientifiques (Tigan, 2005; Paulus, 2000; Richardson, 2005; Johnson et al., 2004; Mathers, Parry et Jones, 2008; Dinham, 2005).
In "Niu dashu tigan" [TEXT NOT REPRODUCIBLE IN ASCII] ("Uncle Niu Promoted," 1995), scripted by Cui Kai, Zhao plays Uncle Niu, who is sent by a poverty-stricken village school to a local government-sponsored company seeking some funding.
To confirm the significance of the results we analyzed the data using epi-info program epidemiologic WHO Geneva 1995 (Tigan et al, 2000).
De aceea, denumirea de tigani o intalnim in cele mai multe limbi europene ca: tigan, zingari, tsigani, cigani, cikani, gitanos etc.
Joe Redden Tigan; WAGGLE; iUniverse (Fiction) $14.95 ISBN: 9781935278122
But Bridgend father and daughter Mark Morgan, 45, and 10-year-old Tigan said the tour's producers should offer fans a refund on their pounds 36 tickets, as all the advertised acts would not take to the stage.
Phenergan, Tigan, Compazine, Vistaril) provide considerable relief.