ticlopidine


Also found in: Dictionary, Wikipedia.
Related to ticlopidine: dipyridamole, ticlopidine hydrochloride

ticlopidine

 [ti-klo´pĭ-dēn]
a platelet inhibitor used as the hydrochloride salt in the prevention of stroke syndrome.

ticlopidine

(tī-klō′pə-dēn′)
n.
A drug that blocks platelet aggregation, C14H14ClNS, used in its hydrochloride form to prevent stroke and to treat intermittent claudication.

ticlopidine

Therapeutics A platelet aggregation inhibitor that alters the platelet membrane, interfering with membrane-fibrinogen interaction by blocking platelet gpIIb/IIIa receptor Indications ↓ Stroke in high risk Pts, minimize stroke progression, cerebral ischemia, progression of diabetic retinopathy Side effects BM suppression with severe reversible neutropenia, diarrhea, rash, gastritis or gastric ulcers–nausea, dyspepsia, hemorrhage, thrombocytopenia, ↑ cholesterol. See TIA.

ticlopidine

A thienopyridine drug that interacts with platelet glycoprotein in such a way as to inhibit platelet function. It has been found useful in preventing vein grafts from becoming occluded by thrombosis.
References in periodicals archive ?
Dipyradamole and Ticlopidine were not prescribed to any patient in our set up.
* 4.0% with 100 mg standardized French maritime pine bark plus 100 mg aspirin (or ticlopidine), and
All patients received oral aspirin (100 mg/day) plus clopidogrel (75 mg/day) or ticlopidine (250 mg twice a day) for the first 3 months, followed by aspirin alone for 9 months.
Metabolism and disposition of the thienopyridine antiplatelet drugs ticlopidine, clopidogrel, and prasugrel in humans.
Clopidogrel is a second-generation thienopyridine, having better efficacy of ticlopidine that represents the first-generation; it has better tolerability profiles and is currently the antiplatelet treatment of choice for prevention of thrombosis events [24, 25].
Beraprost and ticlopidine inhibit small aggregate formation in BRVO patients and may represent effective antiplatelet treatments [189].
A single dose of Ginkgo biloba extract 80 mg, 120 mg, or 240 mg did not significantly alter the pharmacokinetics and antiplatelet activity of ticlopidine, cilostazol, and clopidogrel in healthy volunteers [80, 81].
Rifampin induces CYP-2C19 activity, while the antidepressants fluvoxamine, fluoxetine, and the antithrombotic Ticlopidine inhibit it [25].
Platelet P2Y12 inhibitors (ticlopidine, clopidogrel, prasugrel, and ticagrelor) are used in the management of patients with coronary artery disease (CAD) who experience acute coronary syndrome (ACS) and/or undergo percutaneous coronary intervention (PCI) and to prevent stroke.
Exclusion criteria: Patients with diabetes, platelet adhesion defects such as von Willebrand disease, Bernard-Soulier syndrome or platelet aggregation defects such as Glanzmann's thrombasthenia, afibrinogenemia; history of an infectious disease in the last 10 days and use of at least one of following drugs in the last two weeks: acetylsalicylic acid, clopidogrel, ticlopidine, beta lactam antibiotics, corticosteroids and non-steroidal anti-inflammatory drugs.
Protective effect of ticlopidine on experimentally induced peripheral arterial occlusive disease in rats.
They computed the risks of a number of neonatal outcomes in a multivariate analysis that controlled for hypertensive and thyroid disorders and for several drugs, including antithrombotics, antiplatelets, and ticlopidine. These drugs were chosen as indicators of high-risk pregnancy.