Dipyradamole and Ticlopidine
were not prescribed to any patient in our set up.
* 4.0% with 100 mg standardized French maritime pine bark plus 100 mg aspirin (or ticlopidine
All patients received oral aspirin (100 mg/day) plus clopidogrel (75 mg/day) or ticlopidine
(250 mg twice a day) for the first 3 months, followed by aspirin alone for 9 months.
Metabolism and disposition of the thienopyridine antiplatelet drugs ticlopidine
, clopidogrel, and prasugrel in humans.
Clopidogrel is a second-generation thienopyridine, having better efficacy of ticlopidine
that represents the first-generation; it has better tolerability profiles and is currently the antiplatelet treatment of choice for prevention of thrombosis events [24, 25].
Beraprost and ticlopidine
inhibit small aggregate formation in BRVO patients and may represent effective antiplatelet treatments .
A single dose of Ginkgo biloba extract 80 mg, 120 mg, or 240 mg did not significantly alter the pharmacokinetics and antiplatelet activity of ticlopidine
, cilostazol, and clopidogrel in healthy volunteers [80, 81].
Rifampin induces CYP-2C19 activity, while the antidepressants fluvoxamine, fluoxetine, and the antithrombotic Ticlopidine
inhibit it .
Platelet P2Y12 inhibitors (ticlopidine
, clopidogrel, prasugrel, and ticagrelor) are used in the management of patients with coronary artery disease (CAD) who experience acute coronary syndrome (ACS) and/or undergo percutaneous coronary intervention (PCI) and to prevent stroke.
Exclusion criteria: Patients with diabetes, platelet adhesion defects such as von Willebrand disease, Bernard-Soulier syndrome or platelet aggregation defects such as Glanzmann's thrombasthenia, afibrinogenemia; history of an infectious disease in the last 10 days and use of at least one of following drugs in the last two weeks: acetylsalicylic acid, clopidogrel, ticlopidine
, beta lactam antibiotics, corticosteroids and non-steroidal anti-inflammatory drugs.
Protective effect of ticlopidine
on experimentally induced peripheral arterial occlusive disease in rats.
They computed the risks of a number of neonatal outcomes in a multivariate analysis that controlled for hypertensive and thyroid disorders and for several drugs, including antithrombotics, antiplatelets, and ticlopidine
. These drugs were chosen as indicators of high-risk pregnancy.