A protein that participates in iodine metabolism in the thyroid follicle or in the follicular space; it used H2O2 to produce I+.
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Thyroperoxidase a 105kDa glycoprotein which catalyses iodine oxidation and thyroglobulin tyrosyl iodination reactions in the thyroid gland and is essential for active thyroid hormone T4 and T3 synthesis.
Tiered high-throughput screening approach to identify thyroperoxidase inhibitors within the ToxCast phase I and II chemical libraries.
As stated previously, thyroid function laboratory tests should be routinely performed in patients who present with complaints of widespread pain and fatigue in order to rule out overt hypothyroidism as the cause of these symptoms, including thyroperoxidase and thyroglobulin antibody tests to screen for cases of autoimmune thyroid conditions such as Graves' disease and Hashimoto's thyroiditis.
Test TPOAb TRAb Synonym Thyroid microsomal TBII,TSH binding antibodies, inhibiting thyroperoxidase immunoglobulin, antibodies thyrotropin-binding inhibitory immunoglobulin, thyroid binding inhibiting immunoglobulin Clinical Most sensitive test for Establishes Graves utility thyroid autoimmune disease as etiology of disorders (Hashimoto and thyrotoxicosis, Graves) and distinguishes particularly in patients them from with ambiguous clinical non-immune-mediated or biochemical findings, causes of thyroid and/or ambiguous/ disorders contraindicated thyroid radioisotope scans (e.
Efficacy and safety of omalizumab patients with chronic urticaria who exhibit IgE against thyroperoxidase.
Objective: For the synthesis of thyroid hormones, thyroperoxidase requires iron.
8-14) The transcription factors control the expression of thyroglobulin (TGB), thyroperoxidase (TPO), thyroid-stimulating hormone receptor, and thyroid iodine transporter.
Moreover, the aforementioned factors play a role in the manifestation of hypothyroidism and exacerbation of autoimmune process in patients with previously demonstrated thyroperoxidase (ATPO) and thyroglobulin (ATG) autoantibodies [5-9].
Therefore many physicians will routinely screen their patients with type I diabetes for AITD by testing for thyroperoxidase (TPOA) and thyroglobulin (TGA) autoantibodies, and will screen for chronic lymphocytic gastritis by testing for gastric parietal cell autoantibodies or intrinsic factor autoantibodies.
It came as a shock to see blood test results with elevated thyroperoxidase (TPO) and thyroglobulin (TG) antibodies, and a TSH around 5.
3% each year, if thyroperoxidase (TPO) antibodies are absent or present respectively.