A protein that participates in iodine metabolism in the thyroid follicle or in the follicular space; it used H2O2 to produce I+.
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Analytical and clinical performance goals for testing autoantibodies to thyroperoxidase, thyroglobulin, and thyrotropin receptor.
Blood tests revealed hyperglycemia (173 mg/dL, reference range 65-110 mg/dL), elevated glycosylated hemoglobin (8.33%, reference range 0.10-6.00%), as well as an abnormal thyroid function represented by thyroperoxidase antibodies level 10 times greater than normal (170 UI/mL, reference range 10-35 UI/mL), decreased levels of free T3 (3.55 pmol/L, reference range 4-8.3 pmol/L) and free T4 (8.61 pmol/L, reference range 10-20 pmol/L) and elevated levels of thyroid stimulating hormone (18.91 [micro]UI/mL, reference range 0.2-5 [micro]UI/mL).
Thyroperoxidase (TPO) is an enzyme involved in thyroid hormone synthesis, catalysing the oxidation of iodide on tyrosine residues in thyroglobulin for the synthesis of triiodothyronine and thyroxine (Tetraiodothyronine).
Association of first-trimester thyroid function test values with thyroperoxidase antibody status, smoking, and multivitamin use.
Efficacy and safety of omalizumab in patients with chronic urticaria who exhibit IgE against thyroperoxidase. J Allergy Clin Immunol.
Here we report four patients with Hashimoto encephalopathy who had neuro-psychiatric manifestations of the disease and had detectable thyroid specific antibodies in the serum (thyroperoxidase antibody formerly known as anti-microsomal antibody).
(7) Hashimoto's thyroiditis characterized by high rates of the antibodies antithyroglobulin (TG) and thyroperoxidase (TPOAb), and by infiltration of T and B cells, which contribute to gland deterioration and exacerbation of symptoms.
For example, AvRuskin and Juan [59] reported a 30-year-old Hispanic male who showed transient neonatal diabetes mellitus at 4 months and was diagnosed with hypothyroidism with positive thyroperoxidase antibodies.
Azizi, "The association of cigarette smoking with serum TSH concentration and thyroperoxidase antibody," Experimental and Clinical Endocrinology & Diabetes, vol.
Tiered high-throughput screening approach to identify thyroperoxidase inhibitors within the ToxCast phase I and II chemical libraries.
Her thyroid function tests were as follows: total [T.sub.3] 2.4 ng/mL (0.9-2.3), free T3 6.17 pg/mL (1.7-3.7), total [T.sub.4] 12.9 [micro]g/dL (5.9-12.9), free [T.sub.4] 2.33 ng/dL (0.7-1.48), TSH 3.29 [micro]IU/mL, thyroglobulin 15.2 ng/mL (0.2-70), and negative antibodies of thyroglobulin and thyroperoxidase. In the genetic analysis of the patient suspected of having thyroid hormone resistance, the P453A c.1357C > G mutation was detected to be heterozygous on the exon 10 of the THRB gene.
Essential for thyroid organogenesis, TTF1 helps modulate thyroid function through its regulation of gene expression in the thyroid, activating the transcription of thyroid-specific genes like thyroglobulin (TG) and thyroperoxidase (TPO) (69,70).