NKX2-1

(redirected from Thyroid Transcription Factor 1)
Also found in: Acronyms.

NKX2-1

A gene on chromosome 14q13 that encodes a transcription factor which binds and activates the promoter of thyroid-specific genes—e.g., for thyroglobulin, thyroperoxidase and thyrotropin receptor. NKX2-1 is crucial in the maintenance of the thyroid differentiation phenotype, and it may play a role in lung development and surfactant homeostasis.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
The tumor cells are negative for both thyroid transcription factor 1 (D) and napsin A (E) (hematoxylin-eosin, original magnification X400 [A]; original magnification X400 [B through E]).
The tumor cells are positive for thyroid transcription factor 1 (B) and napsin A (C).
Use of thyroid transcription factor 1, PE-10, and cytokeratins 7 and 20 in discriminating between primary lung carcinomas and metastatic lesions in fine-needle aspiration biopsy specimens.
A through F, The RNAscope assay results for thyroid transcription factor 1 expression in lung adenocarcinomas from 0 (negative) to [4.sup.+]: A, 0 (negative); B, [1.sup.+]; C, [2.sup.+]; D, [3.sup.+]; E and F, [4.sup.+] (original magnification X400 [A through F]).
Thyroid transcription factor 1 expression by immunohisto-chemical analysis was initially exclusively identified in thyroid and lung epithelial tissues, including normal, benign, and malignant tissues.
Immunostaining for thyroid transcription factor 1 and cytokeratin 20 aids the distinction of small cell carcinoma from Merkel cell carcinoma, but not pulmonary from extrapulmonary small cell carcinomas.
Thyroid transcription factor 1 positive NECs appear to correlate with primary lung origin, although this is not specific as it is in ADC.
Large cell carcinoma with undifferentiated and basaloid components and with strong thyroid transcription factor 1 (TTF-1) expression.
Thyroid transcription factor 1 is a 38-kDa homeodomain protein that shows nuclear-specific staining.
We rely on TTF1 (thyroid transcription factor 1) primarily as a diagnostic marker and have been using napsin A when TTF1 results are negative, weak, or inconclusive, for example, with poorly differentiated adenocarcinoma.
Previously performed immunohistochemical stains for thyroid transcription factor 1 (TTF-1) (n = 5) and cytokeratins (AE1/AE3 + CAM5.2 cocktail, 3 cases; AE1/AE3, 1 case; cytokeratin 7, 1 case) were reviewed if available.
The antibodies used included prostate-specific antigen (PSA); [alplha]-methylacyl-CoA racemase, high-molecular-weight cytokeratin and p63 protein cocktail (PIN4); cytokeratin 7 (CK7); cytokeratin 20 (CK20); epithelial membrane antigen (EMA); mucin type 1 sialoglycoprotein (MUC1); cluster of differentiation 31/platelet-endothelial cell adhesion molecule 1 (CD31); thyroid transcription factor 1 (TTF1); caudal-related homeobox 2 (CDX2); and Wilms tumor protein 1 (WT1).