Mechanisms of acquired thymic tolerance in vivo : Intrathymic injection of antigen induces apoptosis of thymocytes
and peripheral T cell anergy.
lineage commitment: is it instructed or stochastic?
The cortex had a large number of thymocytes
. The medulla was located in the core of the thymus.
Cortical ERC's acting as the antigen presenting cells are involved with the positive selection of thymocytes
while the medullary ERC's, through negative selection establish a self tolerant repertoire of T cells4.
Type B thymomas were further subdivided based on the proportional increase in tumor cells in relation to thymocytes
, increasing cytologic atypia, and presence or absence of medullary differentiation.
The expression of NIS and TSHR was mainly observed in Hassall's corpuscles and in thymocytes
of the thymic medulla (Figure 2(a)).
Early thymic progenitor cells originating in the bone marrow enter the thymus at the corticomedullary junction and move into the cortex where they differentiate into T cell receptor(TCR-) expressing [CD4.sup.+][CD8.sup.+] double-positive (DP) thymocytes
Kenji Nihei et al., "Altered expression of galectin-3 induces cortical thymocyte
depletion and premature exit of immature thymocytes
during Trypanosoma cruzi infection," The American Journal of Pathology, vol.
Perillo et al., "Human thymic epithelial cells express an endogenous lectin, galectin-1, which binds to core 2 O-glycans on thymocytes
and T lymphohlastoid cells," Journal of Experimental Medicine, vol.
The procedure detects T cell receptor excision circles (TRECs), which are pieces of DNA that are excised and form circles within thymocytes
when the T cell receptor genes undergo rearrangement.
In a previous study, MIMP was diminished in mouse thymocytes
treated with 10 nM TBTC (Sharma and Kumar 2014).
In fact, GSH-depleted thymocytes
were more susceptible to apoptosis  whereas NAC appears to inhibit GSH depletion and enhance lymphocyte survival .