DNA damage results when UV light induces covalent bonds between nucleic acid base pairs and forms thymine dimers, which can alter tumor suppressor gene p53 function, thereby increasing the risk of cutaneous cancers and aging.
Topical application of ascorbic acid, along with vitamin E and ferulic acid, has been demonstrated to decrease the formation of thymine dimers.
One day later, skin was evaluated for erythema and sunburn cells, and immunohistochemically for thymine dimers and p53.
The topical combination was particularly effective for reducing thymine dimer mutations which are associated with skin cancer," explained Jacknin.
Specifically, UV-C light causes damage to the nucleic acid of microorganisms by the formation of lethal thymine dimers
on the microbial DNA.
Effect of Intense pulsed-light exposure on lipid peroxides and thymine dimers
in human skin in vivo.
Clearly, it has the propensity to prevent cellular damage, as measured by sunburned cells and thymine dimers.
Compared with placebo, treated individuals with low baseline MED had a 50% reduction in epidermal sunburned (apoptotic) cells and nearly a 60% reduction in DNA damage, as measured by thymine dimer formation.
For years, thymine dimers
were considered to be the classic sign of UV damage to DNA.
According to company executives, efficacy tests have demonstrated DN-AGE LS 9653's ability to protect both nuclear and mitochondrial DNA, reducing the formation of thymine dimers
caused by UVB absorption and stimulating the natural DNA repair process in skin cells.
Compared with placebo, individuals with low baseline MED who were administered the hormone demonstrated a 50% reduction in epidermal sunburned (apoptotic) cells and nearly a 60% reduction in DNA damage, as measured by thymine dimer