thymidylate synthase


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thy·mi·dyl·ate syn·thase

(thī'mi-dil'āt sin'thās),
An enzyme catalyzing conversion of deoxyuridine 5'-monophosphate to thymidine 5'-monophosphate, the methyl group coming from N5,N10-methylenetetrahydrofolate.
References in periodicals archive ?
Saviozzi et al., "Squamous cell carcinoma of the lung compared with other histotypes shows higher messenger RNA and protein levels for thymidylate synthase," Cancer, vol.
Zhou et al., "Polymorphisms of thymidylate synthase in the 5'- and 3'-untranslated regions and gastric cancer," Digestive Diseases and Sciences, vol.
Lack of immunohistochemical expression of thymidylate synthase has been found to be associated with tumor downstaging after preoperative chemoradiotherapy but not after radiotherapy.
Ichikawa et al., "Impact of the expression of thymidylate synthase and dihydropyrimidine dehydrogenase genes on survival in stage II/III gastric cancer," Gastric Cancer, vol.
Loss of heterozygosity at the thymidylate synthase (TS) locus on chromosome 18 affects tumor response and survival in individuals heterozygous for a 28-bp polymorphism in the TS gene.
Polymorphisms in the thymidylate synthase and methylenetetrahydrofolate reductase genes and sensitivity to the low-dose methotrexate therapy in patients with rheumatoid arthritis.
Principally, the intermediate metabolite fluorodeoxj uridine monophosphate inhibits a key enzyme in pyrimidine biosynthesis, namely thymidylate synthase (TS).
Expression of thymidylate synthase (TS; target for 5FU) and dihydropyrimidine dehydrogenase (DPDY; 5FU metabolizing enzyme) have been correlated with resistance to 5FU (Zhang et al.
The proprietary ResponseDX(tm) panels include four key genes: excision repair cross-complementing factor 1 (ERCC1), thymidylate synthase (TS), human epidermal growth factor receptor 2 (HER2) and epidermal growth factor receptor expression (EGFR).
Seven functional polymorphisms and six genes in the folate homocysteine pathway were considered: 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C > T, MTHFR 1298A > C, cystathionine [beta] synthase (CBS) 844ins68, methionine synthase (MTR) 2756A > G, methionine synthase reductase (MTRR) 66A > G, thymidylate synthase (TYMS) 1494del6, and dihydrofolate reductase (DHFR) c.86 + 60_78 in 163 SLE patients and 160 controls.
Markers related to response to 5-FU 5-FU is an inhibitor of thymidylate synthase (TS), an essential enzyme for DNA synthesis [20].
Their inspiration: thymidylate synthase A, or ThyA, a protein that in a flawed form plays a part in types of cancer.