Biopharmaceutical company Modis Therapeutics revealed on Tuesday the receipt of European Medicines Agency (EMA) PRIME (PRIority MEdicines) designation for its investigational MT1621 for patients with thymidine kinase
2 deficiency (TK2d).
The liver regeneration parameters (thymidine kinase
, regeneration rate, mitotic index) and antioxidant enzyme levels (glutathione reductase, myeloperoxidase, MDA levels) were showed to be significant differences among the sham, control, FK506 and EGb761 + FK506 groups (p<0.05).
The cytosolic activity of thymidine kinase
(TK) was assayed according to Sauer and Wilmanns ; briefly: cytosolic samples were incubated with a reaction mixture consisting in 0.2 mol/L Tris-HCl pH 8.0,10 mmol/L EDTA, 20 mmol/L Mg[Cl.sub.2], 40 mmol/L ATP, 450 [micro]mol/L thymidine, and 4.5 [micro]Ci [[sup.3]H]-Thymidine for one hour at 37[degrees]C.
In 2007, a separate group of workers individually cloned and expressed BTV proteins into the thymidine kinase
gene of the Kenya Sheep (KS-1) vaccine strain of capripoxvirus.
Biovica has acquired cSens AB, a company that has developed a PCR-based platform for the analysis of serum thymidine kinase
(TK) enzyme activity, which correspond to tumor proliferation and cancer aggressiveness.
HSV-1 codes for its own thymidine kinase
allowing it to replicate in both dividing and non-dividing cells, however dlsptk is tk-null.
Nucleotide sequences of the hemagglutinin, thymidine kinase
, and A-type inclusion body protein genes were identical to those of CPXV strains T2000 and E1989 previously identified in Finland (3).
More recently, a gE and thymidine kinase
double deletion BoHV-5 recombinant strain was constructed and proposed as a candidate vaccine strain (14).
Patients received injections of an adenoviral vector containing a herpes simplex thymidine kinase
gene with no systemic immune response.
It preferentially hit tumor cells because the researchers had engineered the virus to lack an enzyme called thymidine kinase
, which it needs.
Their antiviral effect is dependent on the phosphorylation of viral thymidine kinase
In addition, the serum concentrations of thymidine kinase
, [[beta].sub.2] microglobulin, and soluble CD23 have also been reported to help improve prognostication in CLL (5).