I also briefly summarize the biochemical and pathophysiological properties of the two other PGE synthases (PGESs) and thromboxane synthase
(TXS), which is closely related to PGIS.
2]), which is produced by the action of thromboxane synthase
on the prostaglandine endoperoxide [H.
The VCU team reported that thromboxane synthase
- an important inflammatory enzyme - is increased in the blood vessels of expectant mothers with preeclampsia.
One enzyme, thromboxane synthase
, is responsible for cancer cells spreading quickly through the body.
In addition to the development of EV-077 for complications of diabetes, Evolva has been investigating a novel anti-viral property of this dual thromboxane receptor antagonist and thromboxane synthase
It's irreversible and goes primarily down one of those pathways; it blocks thromboxane synthesis in platelets by inhibiting thromboxane synthase
, which is an enzyme in the platelet itself, so we think our mechanism of action is broader.
The trials involved endothelin-receptor antagonists, thromboxane synthase
inhibitors, prostanoids, and phosphodiesterase type-5 inhibitors.
Inhibition of Thromboxane Synthase
Leads to Cell Cycle Arrest and Apoptosis in Lung Cancer Cells
We incubated additional aliquots with 1 /,mol/L terbogrel (Thomae), an equipotent inhibitor of thromboxane synthase
and thromboxane receptors.
The reduction in thromboxane A2 synthase activity was confirmed in a separate study in which thromboxane synthase
receptor inhibition was evident after exposure to 1-TDC.
In addition to the development of EV-077 for cardio-renal indications, Evolva has been investigating a novel anti-viral property of this dual thromboxane receptor antagonist and thromboxane synthase
Deficiencies of the enzymes cyclooxygenase and thromboxane synthase
are well-documented, and dysfunction or deficiency of thromboxane receptors is known.