thromboxane-A synthase

(redirected from Thromboxane synthase)

thromboxane-A synthase

an enzyme that catalyzes the conversion in platelets of prostaglandin G2 to thromboxane A2. A deficiency of the enzyme causes a defect in the release of platelets. See also thromboxane A2.
References in periodicals archive ?
2]), which is produced by the action of thromboxane synthase on the prostaglandine endoperoxide [H.
Preliminary clinical studies with thromboxane synthase inhibitors and thromboxane receptor blockers.
The VCU team reported that thromboxane synthase - an important inflammatory enzyme - is increased in the blood vessels of expectant mothers with preeclampsia.
One enzyme, thromboxane synthase, is responsible for cancer cells spreading quickly through the body.
It's irreversible and goes primarily down one of those pathways; it blocks thromboxane synthesis in platelets by inhibiting thromboxane synthase, which is an enzyme in the platelet itself, so we think our mechanism of action is broader.
The trials involved endothelin-receptor antagonists, thromboxane synthase inhibitors, prostanoids, and phosphodiesterase type-5 inhibitors.
Inhibition of Thromboxane Synthase Leads to Cell Cycle Arrest and Apoptosis in Lung Cancer Cells
In these in vitro studies, Celadrin(R) was shown to inhibit the thromboxane synthase enzyme using prostaglandin G2 (PGG2) and prostaglandin H2 (PGH2) as substrates.
We incubated additional aliquots with 1 /,mol/L terbogrel (Thomae), an equipotent inhibitor of thromboxane synthase and thromboxane receptors.
The reduction in thromboxane A2 synthase activity was confirmed in a separate study in which thromboxane synthase receptor inhibition was evident after exposure to 1-TDC.
Deficiencies of the enzymes cyclooxygenase and thromboxane synthase are well-documented, and dysfunction or deficiency of thromboxane receptors is known.
Exogenous AA is converted into prostaglandin endoperoxides by cytosolic cyclooxygenase (COX) and then converted by thromboxane synthase to thromboxane [A.