thromboxane A2


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thromboxane A2

(throm-bok'san),

TXA2

An unstable compound synthesized in platelets and other cells from a prostaglandin, PGH2. It acts to aggregate platelets, is a potent vasoconstrictor, and mediates inflammation.
See: eicosanoid; prostaglandin; prostanoids
References in periodicals archive ?
Dileepan, "Increased aortic atherosclerotic plaque development in female apolipoprotein E-null mice is associated with elevated thromboxane A2 and decreased prostacyclin production," Journal of Physiology and Pharmacology : An Official Journal of the Polish Physiological Society, vol.
Flavonoids inhibit platelet function through binding to the thromboxane A2 receptor.
Willerson, "Effects of serotonin and thromboxane A2 on the coronary collateral circulation," Journal of the American College of Cardiology, vol.
Picotamide: It is a combined inhibitor of thromboxane A2 synthase and receptor and, at variance with aspirin, does not interfere with endothelial prostacyclin (PGI2) production.
Increased synthesis of thromboxane A2 and expression of procoagulant activity by monocytes in response to arachidonic acid in diabetes mllitus.
For example, low-dose aspirin protects against heart attacks and strokes by blocking COX-1 from forming a prostaglandin called thromboxane A2 in platelets.
Subsequent steps in wound healing involve arachidonic acid metabolites that are derived from cell membrane fatty acids, which play central roles in the regulation of vasomotor and platelet activity after injury, while thromboxane A2 helps with hemostasis by its effects on vasoconstriction and platelet aggregation.
The findings of the study are however in line with those of previous studies, which have shown higher circulating levels of other potent vasoconstrictors such as endothelin-1 (ET-1) and thromboxane A2 (TX-A2) in patients with no-reflow (7, 8).
(11) These collagen fibrils not only provide a surface for platelet adhesion, but also serve as a strong stimulus for platelet activation, which includes secretion of thromboxane A2 and ADP into the circulation.
These researchers have identified "whole blood choline as a potential marker reflecting coronary plaque instability, platelet activation, and tissue ischemia." A standard treatment for patients with troponin-positive acute coronary syndrome is tirofiban which is a "short-acting non-peptide inhibitor of the GPIIb/IIIA receptor." (3) Aspirin and clopidogrel represent current standard antiplatelet agents blocking platelet cyclooxygenase-1 and thromboxane A2. This new drug is associated with a lower incidence of ischemic events.
Nitric oxide, Bradykinin, Prostacyclin, Serotonin, Histamin, Substance P and Endothelium- derived hyperpolarizing factor are the vasodilators while the substances like Angiotensin, Endothelin (ETI), Thromboxane A2, Serotonin, Arachidonic acid, Prostaglandin H2 and Thrombin are the vasoconstrictor molecules released by the endothelium (16).