thrombospondin

(redirected from Thrombospondin repeats)

thrombospondin

/throm·bo·spon·din/ (throm″bo-spon´din) a glycoprotein that interacts with a wide variety of molecules, including heparin, fibrin, fibrinogen, platelet cell membrane receptors, collagen, and fibronectin, and plays a role in platelet aggregation, tumor metastasis, adhesion of Plasmodium falciparum, vascular smooth muscle growth, and tissue repair in skeletal muscle following crush injury.

thrombospondin

(throm″bō-spon′dĭn),

TSP

A glycoprotein that prevents cell-to-cell adhesion and angiogenesis. Thrombospondin is secreted by some parasites and may enhance their ability to cause disease. It is also found in malignant tumors, where it may block tumor growth and metastasis.

thrombospondin

an osteoblast product which binds to connective tissues and serum proteins and binds calcium to hydroxyapatite and to osteonectin.
References in periodicals archive ?
George (2007) explains that ADAMTS 13 is an acronym for a disintegrin and metalloprotease with thrombospondin repeats that acts as a Von Willebrand Factor, VWF-cleaving protease.