CD36

(redirected from Thrombospondin receptor)

CD36

a transmembrane protein present on monocytes, platelets, megakaryocytes, the umbilical vein, small-vessel endothelium, reticulocytes, and mammary epithelium that may be involved in signal transduction; expressed in myeloproliferative disorders.
Farlex Partner Medical Dictionary © Farlex 2012

CD36

A gene on chromosome 7q11.2 that encodes the fourth major platelet surface glycoprotein, which is a receptor for thrombospondin. It is acts as a cell adhesion molecule, binding to collagen, thrombospondin, anionic phospholipids, oxidised LDL, long-chain fatty acids and Plasmodium falciparum-parasitised erythrocytes.
 
Molecular pathology
Defects in CD36 cause platelet glycoprotein deficiency; genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Susman et al., "Gabapentin receptor a.28-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis," Cell, vol.
Susman et al., "Gabapentin receptor [alpha]2[delta]-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis," Cell, vol.
Reichardt, "Identification of integrin [alpha]3/[beta] as a neuronal thrombospondin receptor mediating neurite outgrowth," Neuron, vol.