thrombophlebitis

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Thrombophlebitis

 

Definition

Thrombophlebitis is the inflammation of a vein with blood clot formation inside the vein at the site of the inflammation. Thrombophlebitis also is known as phlebitis, phlebothrombosis, and venous thrombosis.

Description

There are two parts to thrombophlebitis, inflammation of a vein and blood clot formation. If the inflammation is minor, the disease usually is called venous thrombosis or phlebothrombosis. Thrombophlebitis can occur in both deep veins and superficial veins, but most often occurs in the superficial veins of the extremities (legs and arms). Most cases occur in the legs. When thrombophlebitis occurs in a superficial vein, one that is near the surface of the skin and is visible to the eye, the disease is called superficial thrombophlebitis. Any form of injury to a blood vessel can result in thrombophlebitis. In the case of superficial thrombophlebitis, the blood clot usually attaches firmly to the wall of the affected blood vein. Since superficial blood veins do not have muscles that massage the veins, blood clots in superficial veins tend to remain where they form and seldom break loose. When thrombophlebitis occurs in a deep vein, a vein that runs deep within muscle tissue, it is called deep venous thrombosis. Deep venous thrombosis presents the threat of producing blood clots that will break loose to form emboli. These can lodge in other tissues where they can block the blood supply, typically in the lungs. This results in tissue damage and can sometimes be serious or fatal, for example; pulmonary embolism.

Causes and symptoms

The main symptoms are tenderness and pain in the area of the affected vein. Redness and/or swelling also may be seen. In the case of deep venous thrombosis, there is more swelling than is caused by superficial thrombophlebitis, and the patient may experience muscle stiffness in the affected area. There are many causes of thrombophlebitis.
The main causes can be grouped into three categories; injury to blood veins, increased blood clotting, and blood stasis. When blood veins are damaged, collagen in the blood vein wall is exposed. Platelets respond to collagen by initiating the clotting process. Damage to a vein can occur as a consequence of indwelling catheters, trauma, infection, Buerger's disease, or the injection of irritating substances. Increased tendency of the blood to clot can be caused by malignant tumors, genetic disorders, and oral contraceptives, though newer generation birth control pills carry a lower risk for many women. Stasis, in which the blood clots due to decreased blood flow in an area, can happen following surgery, as a consequence of varicose veins, as a complication of postpartum states, and following prolonged bed rest. In the case of prolonged bed rest, blood clots form because of inactivity, which allows blood to move sluggishly and stagnate (collect) in blood veins. This can lead to blood clots. These clots (also called emboli) sometimes are released when the patient stands up and resumes activity. This can present a problem if the emboli lodge in vital organs. In the case of postpartum patients, a fever developing four to 10 days after delivery may indicate thrombophlebitis. A 2004 study revealed that postmenopausal women taking hormone therapy combining estrogen and progestin had more than a twofold higher risk of venous thrombosis than non-hormone users.

Diagnosis

In superficial thrombophlebitis, the location of the clot sometimes can be seen by the unaided eye. Blood clots are hard and can usually be detected by a physician using palpation (touching or massage). Deep venous thrombosis requires specialized diagnostic procedures to detect the blood clot. Among the exams a physician may use are ultrasound and x ray, coupled with dye injection (venogram).

Treatment

Superficial thrombophlebitis usually resolves without treatment. If treatment of superficial thrombophlebitis is given, it usually is limited to the application of heat or anti-inflammatory drugs, like aspirin or ibuprofen, which also help to relieve the pain. It can take from several days to several weeks for the clot to resolve and the symptoms to completely disappear. A 2003 study showed that low intensity therapy with warfarin, a common blood thinner, prevented recurrent venous thromboembolism in study subjects. A newer anticoagulant called ximelagatran also has been shown as equally or more effective than warfarin in preventing deep vein thrombosis.
Deep venous thrombosis is a serious condition, treated with anticoagulant drugs and by keeping the affected limb elevated. The primary objective in treating deep venous thrombosis is prevention of a pulmonary embolism. The patient usually is hospitalized during initial treatment. The prescribed anticoagulant drugs limit the ability of blood clots to grow and new clots to form. Sometimes, a drug that dissolves blood clots is administered. These drugs must be used with caution because, as the clot dissolves, it may release from the site where it formed and become an embolus. Surgery may be used if the affected vein is likely to present a long-term threat of producing blood clots that will release emboli. When superficial thrombophlebitis occurs in the groin, where the superficial veins join the deep veins, the threat of emboli is present. In this case, blood clots formed in the superficial veins can extend into the much larger deep vein where they break off and are released into the blood stream. The affected veins are either removed or tied off to prevent the release of the blood clots. Tying off superficial blood veins is an outpatient procedure that can be performed with local anesthesia. The patient is capable of immediately resuming normal activities.

Prognosis

Superficial thrombophlebitis seldom progresses to a serious medical complication, although non-lethal embolisms may be produced. Deep venous thrombosis may lead to embolism, especially pulmonary embolism. This is a serious consequence of deep venous thrombosis, and sometimes is fatal.

Resources

Periodicals

Brunk, Doug. "Thrombosis Risk Doubled in Women on Combo HT: Data from WHI Study: Risk Increases With Age, Body Mass Index." Internal Medicine News January 15, 2004: 1-3.
Elliott, William T. "Warfarin Effectively Prevents Venous Thromboembolism." Clinical Cardiology Alert April 2003: 1-2.
"Registrat: The Combined Pill, Part One." GP September 8, 2003: 46.
"WPrevention of VTE With Ximelagatran." Neurology Alert February 2004: SS3-SS5.

Key terms

Emboli, embolus — Emboli is the plural form of embolus. Embolus is any mass of air, blood clot, or foreign body that travels through the blood stream and is capable of lodging in smaller blood vessels where they obstruct the blood flow to that vessel.
Embolism — The obstruction of a blood vessel by a blot clot.
Phlebitis — Inflammation of a vein.
Thrombus — A blood clot that forms within a blood vessel or the heart.

thrombophlebitis

 [throm″bo-flĕ-bi´tis]
inflammation of a vein (phlebitis) associated with formation of a thrombus (thrombosis).
thrombophlebitis mi´grans a recurrent condition involving different vessels simultaneously or at intervals.
postpartum iliofemoral thrombophlebitis thrombophlebitis of the iliofemoral vein following childbirth.

throm·bo·phle·bi·tis

(throm'bō-flĕ-bī'tis),
Venous inflammation with thrombus formation.
[thrombo- + G. phleps, vein, + -itis, inflammation]

thrombophlebitis

/throm·bo·phle·bi·tis/ (-flĕ-bi´tis) inflammation of a vein (phlebitis) associated with thrombus formation (thrombosis).
thrombophlebitis mi´grans  a recurring thrombophlebitis involving different vessels simultaneously or at intervals.
postpartum iliofemoral thrombophlebitis  thrombophlebitis of the iliofemoral vein following childbirth.

thrombophlebitis

(thrŏm′bō-flĭ-bī′tĭs)
n.
Inflammation of a vein caused by or associated with the formation of a blood clot.

thrombophlebitis

[-fləbī′tis]
Etymology: Gk, thrombos + phleps, vein, itis, inflammation
inflammation of a vein accompanied by the formation of a clot. It occurs most commonly as the result of trauma to the vessel wall; hypercoagulability of the blood; infection; chemical irritation; postoperative venous stasis; prolonged sitting, standing, or immobilization; or a long period of IV catheterization. Also called phlebitis.
observations Thrombophlebitis of a superficial vein is generally evident; the vessel feels hard and thready or cordlike and is extremely sensitive to pressure; the surrounding area may be erythematous and warm to the touch, and the entire limb may be pale, cold, and swollen. Deep vein thrombophlebitis is characterized by aching or cramping pain, especially in the calf, when the patient walks or dorsiflexes the foot (Homans' sign).

thrombophlebitis

 Phlebitis, phlebothrombosis Hematology A term that arose when DVT was thought to occur either without inflammation–phlebothrombosis, or with inflammation–thrombophlebitis, a concept that has long since been abandoned; the term continues to be used for inflamed or infected thrombi, which give rise to septic infarcts. See Deep vein thrombosis.

throm·bo·phle·bi·tis

(throm'bō-flĕ-bī'tis)
Venous inflammation with thrombus formation.
[thrombo- + G. phleps, vein, + -itis, inflammation]

thrombophlebitis

Inflammation of a vein (phlebitis) with resulting local clotting of the blood. In a vein near the surface, this causes redness, swelling, acute TENDERNESS and often fever and general upset. Deep vein thrombophlebitis produces similar symptoms but may also lead to the formation of a long, loose, soft, eel-like clot that can break away and cause serious or fatal plugging of the main lung arteries (PULMONARY EMBOLISM).

thrombophlebitis

superficial inflammation of vein wall with thrombus formation, e.g. in saphenous vein in association with varicosity formation; presents as painful, cord-like swelling of affected vein with local redness and swelling; treated by rest and analgesics; anticoagulation/thrombolysis is not usually indicated

throm·bo·phle·bi·tis

(throm'bō-flĕ-bī'tis)
Venous inflammation with thrombus formation.
[thrombo- + G. phleps, vein, + -itis, inflammation]

thrombophlebitis (throm´bōfləbī´tis),

n an inflammation of the vein in which the vein becomes closed or occluded resulting from the development of a clot or thrombus.

thrombophlebitis

inflammation of a vein associated with thrombus formation. See also thrombosis.