thrifty phenotype

(redirected from Thrifty phenotype hypothesis)

thrifty phenotype

An “anaemic” body type that results from malnutrition during foetal and early postnatal life, leading to insulin resistance and metabolic dysfunction as adults.
References in periodicals archive ?
This proposal grew out of the Barker hypothesis which evolved into the Thrifty Phenotype hypothesis.
Type 2 (non-insulin dependent) diabetes mellitus: the thrifty phenotype hypothesis.
But in broad outline, the thrifty phenotype hypothesis holds that in periods of nutritional deprivation, the fetus adopts two strategies to ensure survival: It preferentially shunts blood to the brain from key bodily organs; and during a critical window of intrauterine development it engages in programming of organ structure and function so as to maintain long-term metabolic thriftiness later in life under conditions of poor postnatal nutrition.