In a previous Phase 1 clinical trial, five patients with neurologically complete, thoracic spinal cord
injury were administered two million AST-OPC1 cells at the spinal cord injury site 7-14 days post-injury.
The foundation for the clinical trial comes from results from the phase I clinical trial of AST-OPC1, which met its primary endpoints of safety and feasibility when administered to five patients with neurologically complete, thoracic spinal cord
In adults, cavernomatous malformations occur mostly in thoracic spinal cord
while in children they occur with even distribution in the thoracic and cervical spinal cord.
The open-label, multisite study, will enroll up to eight patients with thoracic spinal cord
injuries (T2-T12), who have an American Spinal Injury Association (ASIS) A level of impairment, between one and two years after injury.
This distribution probably reflects the greater length of the thoracic spinal cord
more than anything else.
Necropsy confirmed the diagnosis of sarcoidosis, which involved extensively the heart, thoracic spinal cord
, and hilar lymph nodes (only one of which was enlarged), and minimally the lung and kidney.
Thoracic spinal cord
compression by a gouty tophus.
The injury zone of the thoracic spinal cord
extracted after euthanasia at 15 weeks had a more myelinated appearance, that is, whiter and less translucent, in the rats that had received prolonged NRM stimulation than in the implant-control group (Figure 3).
314) Acute Cervical or High Thoracic Spinal Cord
Injury: Pathophysiology and Assessment Karen McQuillan, MS RN CCRN CNRN
Zipes and his associates recently documented a major reduction in ischemic ventricular arrhythmias with thoracic spinal cord
stimulation in dogs with healed MI and superimposed heart failure.
Magnetic resonance imaging of the upper lumbar and lower thoracic spine demonstrated an epidural hematoma extending from T8-T12 with displacement and mild compression of the lower thoracic spinal cord
Geron is conducting a Phase 1 clinical trial to assess the safety of GRNOPC1 in patients with complete, thoracic spinal cord