thioredoxin reductase

Also found in: Wikipedia.

thi·o·re·dox·in re·duc·tase

a flavoprotein that uses NADPH to re-reduce thioredoxin in the formation of deoxyribonucleotides.
Farlex Partner Medical Dictionary © Farlex 2012


A gene on chromosome 11q13 that encodes peroxiredoxin 5, which is involved in intracellular redox signalling. It reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided in the thioredoxin system.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Inhibition of certain thiol-containing enzymes (Alcohol dehydrogenase, thioredoxin reductase, RNA polymerase) in the microorganisms by the rapid reaction of thiosulfinates with thiol groups is supposed to be the main mechanism involved in the antibiotic effect.
Thioredoxin (Trx), nicotinamide adenine dinucleotide phosphate (NADPH) and thioredoxin reductase (TrxR) comprise a thioredoxin system which exists in nearly all living cells (Arner and Holmgren 2006).
Effect of thioredoxin reductase 1 on glucocorticoid receptor activity in human outer root sheath cells.
The selenium-containing enzyme thioredoxin reductase 1 (TrxR1) can be used to support the growth of various cells and to protect them from harmful forms of oxygen radicals, known as oxidative stress.
The selected receptors used for the docking studies are carbonic anhydrase II (CA-II), cathepsins B (Cat B) [24], two different DNAs (DNA-1 [25] and DNA-2), DNA gyrase (Gyrase) [26], histone deacetylase7 (HDAC7) [27], histone protein in the nucleosome core particle (HIS) [28], BRAF kinase (Kinase) [29], recombinant human albumin (rHA) [30], ribonucleotide reductase (RNR) [31], topoisomerase II (Top II) [32], thioredoxin reductase (TrxR) [33], and thymidylate synthase (TS) [34].
1.8.1.B1) represents an interesting splicing variant of the animal thioredoxin reductase (TR), featured by the presence of a glutaredoxin-like domain appended at the N-terminal end of the TrxR module [1, 2].
TrxR: Thioredoxin reductase miRNA: MicroRNA UTR: Untranslated region [H.sub.2][]: Hydrogen peroxide.
(iv) Thioredoxin reductase (TR) level: the kits were obtained from Biodiagnostic Company, Egypt, colorimetric method [17].
Yeung et al., "Perturbation of redox balance after thioredoxin reductase deficiency interrupts autophagy-lysosomal degradation pathway and enhances cell death in nutritionally stressed SH-SY5Y cells," Free Radical Biology & Medicine, vol.
Thioredoxin system, composed of thioredoxin reductase (TrxR), thioredoxin (Trx), and NADPH, senses and responds to oxidative stress and modulates the redox status by scavenging ROS and by regulating several redox enzymes and signaling proteins.
Thioredoxin system comprised by thioredoxin reductase (TrxR/TXNDR), thioredoxin (Trx), and NADPH plays an important role in maintaining intracellular redox homeostasis.