thiopurine s-methyltransferase

thiopurine s-methyltransferase

(thī″ŏ-pūr′ēn″es′meth″ĭl-trans′fĕr-ās″),

TPMT

An enzyme that metabolizes and inactivates thiopurines (such as the drugs azathioprine and mercaptopurine). People with a genetic deficiency in TPMT have severe bone marrow suppression when they take thiopurines to manage diseases such as rheumatoid arthritis or inflammatory bowel disease.
References in periodicals archive ?
Adverse reactions to azathioprine cannot be predicted by thiopurine S-methyltransferase genotype in Japanese patients with inflammatory bowel disease.
[3] Human genes: TPMT, thiopurine S-methyltransferase; PACSIN2, protein kinase C and casein kinase substrate in neurons 2; GSTM1, glutathione S-transferase mu 1.
A genetic deficiency in an enzyme which converts 6-mercaptopurine (Thiopurine S-Methyltransferase) as well as polymorphisms in genes for several other components of the same metabolic pathway can lead to hematologic and liver toxicities.
There is no doubt that the thiopurine S-methyltransferase (TPMT) gene polymorphism is one of them.
They are cytochrome P450 2D6 and thiopurine S-methyltransferase (TPMT).
Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms.
Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance.
In a report recently published in this journal (1), Reinshagen et al., who investigated 6-thioguanine nucleotide (6-TGN) concentrations in patients with inflammatory bowel disease (IBD), concluded that standard and adapted dosing of azathioprine led to identical 6-TGN concentrations and remission rates and that therapeutic drug monitoring of thiopurine therapy was of no clinical benefit in patients with a wild-type thiopurine S-methyltransferase (TPMT) genotype.
The thiopurine S-methyltransferase gene locus--implications for clinical pharmacogenomics.
First, there is now a commercially available diagnostic test measuring a patient's ability to produce the metabolic enzyme thiopurine S-methyltransferase (TPMT), which is essential for the metabolism of thiopurine medications used to treat acute lymphoblastic leukemia (ALL), the most common form of childhood cancer.
Thiopurine S-methyltransferase: a genetic polymorphism that affects a small number of drugs in a big way.
Association of inosine triphosphatase 94C>A and thiopurine S-methyltransferase deficiency with adverse events and study drop-outs under azathioprine therapy in a prospective Crohn disease study.