thioester


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thi·o·es·ter

(thī'ō-es'tĕr),
In enzymology, an ester where the oxygen bridging the substrate or product carbonyl carbon and the enzyme is replaced by a sulfur (usually through a Cys residue); a high-energy intermediate in many enzymes.
Synonym(s): acylmercaptan
References in periodicals archive ?
Thioester is an organic compound which is formulated after the esterification of carboxylic acids and thiols.
Summary: Thioester is an organic compound which is formulated after the esterification of carboxylic acids and thiols.
The biological functions of the isopeptide and ester cross-links appear to be conferral of incredible mechanical, chemical and thermal stability, while thioester cross-link function in adhesion to host tissue via formation of a strong covalent bond.
It is characterized by particular reactivity to thiol, indole, imidazole, phenolic, thioester and methionyl groups, leading to oxidative damage to the polypeptide chains and loss of biological function of the proteins [12,13].
The HIS 194 is responsible for the activation of CYS 166 and also for the formation of the tetrahedral intermediate, which will later decompose by transferring a hydride to the NAD + cofactor, forming a highly energetic thioester. After phosphorylation, the esther will release the product of the enzymatic catalysis, that is, 1, 3-bisphosphoglycerate.
In 2006, a team of researchers at the University of Illinois at Urbana-Champaign produced an antioxidant treatment using AOXADUR which consists of three additives: aldehyde, thioester, and a caltalyst.
LpxA is thought to catalyze the nucleophilic attack of the glucosamine 3-hydroxyl on the thioester of R-3-hydroxymyristoyl-ACP, and a conserved His (H125 in E.
Hcy is also metabolized to the thioester Hcy-thiolactone in an error-editing reaction in protein biosynthesis when Hcy is erroneously selected in place of Met by methionyl-tRNA synthetase [2].
Among different classes of receptor lipidation, a special attention is paid to S-acylation--the covalent attachment of the long-chain fatty acid palmitate or stearate to cysteine residue(s) via thioester linkages.
Brief Communication: Preparation of 2,5-bis(methylallyl thioester)-thiadiazole with high refractive index and its coatings--Shuqian Zhou, Yajun Mao, and Zhengfa Zhou
This reaction was defined by Knott in 1955 and it was used for the synthesis of 1,3-dicarbonyl compounds from a thioester by Albert Eschenmoser.