thioamide

(redirected from Thioamides)

thi·o·am·ide

(thī'ō-am'īd),
An amide in which S replaces O.

thioamide

, thionamide (thī″ō-am′īd″) [ thio- + amide]
Any drug that inhibits the thyroid gland from making thyroid hormone. Examples include methimazole and propylthiouracil.
References in periodicals archive ?
Unfortunately, serious adverse effects associated with thioamides in humans include idiosyncratic liver damage, agranulocytosis, aplastic anemia, and vasculitis.
It is usually treated by a medicine called thioamides, which may be gradually reduced and then stopped.
After half an hour 2 equivalents of thioamides in 15 mL methanol were added and the solutions were stirred for one hour.
Hadjiliadis et al., "New antimony(III) bromide complexes with thioamides: synthesis, characterization, and cytostatic properties," Inorganic Chemistry, vol.
A combination of second-line drugs used to cure MDR-TB is aminoglycosides such as amikacin and kanamycin, polypeptides such as capreomycin, viomycin, and enviomycin, fluoroquinolones such as ciprofloxacin, levofloxacin, and moxifloxacin, and thioamides such as ethionamide, prothionamide, and cycloserine [27].
These include (1) aminoglycosides such as amikacin and kanamycin; (2) polypeptides such as capreomycin, viomycin, and enviomycin; (3) fluoroquinolones such as ciprofloxacin, levofloxacin, and moxifloxacin; (4) thioamides such as ethionamide and prothionamide; (5) cycloserine; and (6) terizidone [6].
Susceptibility to ethambutol was found in 42% and to thioamides in 82% of candidates for the short regimen.
135[degrees]C: IR ([cm.sup.-1]): 3100-3500 (2 N-H stretching vibration); 1568 (C=C of aromatic ring); 1280 (N-C=S stretching vibration of thioamides); 1087 (s-m; C=S stretching vibration); 711 (C-Cl): [sup.1]H NMR (300.13 MHz, 5): 9.989 (N-H); 7.099-8.411 (Ar-H); 5.379 (NH); 4.111 (CH); 2.198 (C[H.sub.2]); 1.287 (C[H.sub.3]); [sup.13]C NMR (75.5 MHz, 5): 191.21 (C=O); 174.57 (C=S); 128.39-143.31 (Ar-C); 60.78 (CH); 55.06 (CH); 18.49 (C[H.sub.2]); 14.31 (C[H.sub.3]).
For example, the introduction of the compact photosensitive groups (thioamides or N-nitrosamines) in the rhodamine molecule leads to the preparation of the photoactivated fluorescent dyes (PFDs) in the "caged" (closed) form which becomes more hydrophobic and promotes the membrane permeability.
Jagodzmski, "Thioamides as useful synthons in the synthesis of heterocycles," Chemical Reviews, vol.
Thioamides and related structure are ever more becoming essential building blocks for preparing biologically useful probes [1].