Mild hyponatraemia occurs in about 20 per cent of people taking diuretics, but severe hyponatraemia (Na+ less than 120mmol/L) is more commonly seen with thiazide diuretics
. Symptoms range from mild malaise, lethargy, dizziness and nausea to decreased consciousness, seizures and coma.
directly induce osteoblast differentiation and mineralized nodule formation by targeting a NaCl cotransporter in bone.
and ACE inhibitors were the most frequently used as a single drug, and ACE inhibitors were the BP lowering medications more frequently prescribed, but the rate of hypertension control is insufficient.
The distributions of prescription loop (10.7%) or thiazide diuretics
(35.1%), beta-blockers (40.6%), and ACE inhibitors (12.6%) used are shown in [Table 1].
Loop and thiazide diuretics
may cause this clinical picture, but the patient was not taking these drugs.
But research suggests that ACE inhibitors and ARBs aren't as effective in African-Americans, so thiazide diuretics
and CCBs typically are used instead as first-line therapy in these patients.
7 Thiazide Diuretics
The third subclass of diuretics, thiazide diuretics
are prescribed to patients with mild or moderate HTN (Vallerand, Sanoski, & Deglin, 2013).
JNC 8 recommends thiazide diuretics
and CCBs as first-line therapy--a recommendation that is evidence-based.
Washington, June 17 ( ANI ): Researchers at UT Southwestern Medical Center have found that adults over 65 who have recently begun thiazide diuretics
are at a greater risk for developing metabolic-related adverse events.
It may be used alone or given with other classes of antihypertensives, especially thiazide diuretics
Patients on monotherapy were mostly receiving ACE-I/ARB (25, 65.78%) followed by beta blockers (5, 13.15%), CCBs (4, 0.52%), thiazide diuretics
(2, 5.26%) and combined alpha and beta blocker 2 patients (5.26%).