East Coast fever is a tick-borne disease affecting cattle, caused by the protozoan parasite Theileria parva. With a 34 week incubation period and 100% mortality rate in exotic cattle, it has a devastating economic impact on pastoralists and smallholder farmers in Africa.Combining cutting-edge immunology and protein engineering methods, this collaborative research project aims to develop affordable antibody-based therapies for dengue patients and improved vaccines for the control of dengue fever and East Coast fever in both humans and animals.
These tick-borne diseases include, but are not limited to, heartwater disease (Ehrlichia ruminantium) transmitted by Amblyomma hebraeum (bont tick); red water disease (Babesia bigemina) transmitted by Rhipicephalus (Boophilus) decoloratus (blue tick); and East coast fever (Theileria parva parva) and corridor disease (Theileria parva lawrencei) transmitted by Rhipicephalus appendiculatus (brown ear tick).
In a visit to the cattle Camp in Bor, a cattle keeper, Gai Deng told Sudan Tribune that their camp is affected by East Coast Fever, a tick- borne protozoan infection caused by Theileria parva that killed over 10,000 cattle since it started three years ago.
Recently, this new methodology has been used to identify vaccine candidates against the bovine pathogen Theileria parva. The potential use of this powerful technology for the identification of new vaccine candidates described.