Various experimental cell culture studies involving human and some animal species have shown that thyroid hormones have, to some degree, a stimulatory effect on granulosa and/or thecal cells
Ultimately, the granulosa cell layer becomes indistinct and the thecal cell
layer is much regressed.
In addition, hyaluronan synthase 1 may be the dominant enzyme in thecal cells
that produces HA in pig ovaries and stimulates the removal of degenerating follicles and oocytes.
Moreover, both gonads contain interstitial cells (Leydig and thecal cells
Insulin stimulates testosterone biosynthesis by human thecal cells
from women with polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system.
Progesterone is then converted to androstenedione by the actions of the 17[alpha]-hydroxylase and 17,20-lyase enzyme complex, which is present in thecal cells
but not in granulosa cells.
Ebola Virus GP and VP40 Localization in Infected Cell Types of Nonhuman Primates and Guinea Pigs(*) VP40 GP Cell Type ISH IHC ISH IHC Macrophages and monocytes + + + - Fibroblasts + + + + FRC + + + + Epithelia([dagger]) + + + + Ovarian thecal cells
+ + + + Hepatocytes([double dagger]) + + + + Adrenal cortical cells([double dagger]) + + + + Renal PCTs - + - - Vero E6 cells([sections]) ND + ND - 293 cells([sections]) ND + ND - (*) ISH indicates in situ hybridization; IHC, immunohistochemistry; FRC, fibroblastic reticular cells; PCT, proximal convoluted tubule; ND,in situ hybridization not done on these samples; +, cell type was consistently labeled by the stated method; -, cell type was consistently unlabeled.
The TGF-[beta] superfamily factors, in particular GDF9 and BMP15, play a critical role in ovarian architecture and fertility, being essential for the proper follicular growth and development, as well as for the formation, growth and function of granulosa and thecal cells
Unlike the granulosa cell layer, the layer of thecal cells
becomes richly supplied with capillaries.
(luteinized cells within the stroma) produce estrogen, and if present in large enough quantities within a granulosa cell tumor, can cause elevated serum estradiol levels.
Notably, NGF activation of TrkA in cultured thecal cells
is reported to be involved in the disruption of gap junctions (Mayerhofer, 1996).
the oocytes and the differentiation and proliferation of ovarian somatic cells, or granulosa and thecal cells