hyperplasia coupled with enhanced steroidogenic potential of androgen pathway enzymes may contribute to excess androgen production in ovaries of affected women.
Medina, "Insulin stimulates testosterone biosynthesis by human thecal cells
from women with polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system," The Journal of Clinical Endocrinology and Metabolism, vol.
Various experimental cell culture studies involving human and some animal species have shown that thyroid hormones have, to some degree, a stimulatory effect on granulosa and/or thecal cells
In addition, hyaluronan synthase 1 may be the dominant enzyme in thecal cells
that produces HA in pig ovaries and stimulates the removal of degenerating follicles and oocytes.
GCTs are rare sex cord stromal tumours of the ovary, made up of granulosa cells (sex cord) and stromal cells (thecal cells
Regulation of androgen production in cultured human thecal cells
by insulin-like growth factor I and insulin.
These thecal cells
secrete estrogen and hence tumors like fibrothecomas, thecomas may be concomitantly associated with an enlarged uterus, endometrial hyperplasia or frank endometrial carcinoma.
Remaining clusters of mesenchymal cells located between follicles will become thecal cells
. Unlike the developing testis, the mesonephric tubules regress away from the ovary.
In vivo, ovarian hormone production is controlled by the pituitary hormones FSH and LH, which stimulate granulosa and thecal cells
, respectively (Liu and Hsueh 1986).
Most of these cell types also contained GP antigen as well, including hepatocytes; adrenal cortical cells; the epithelium of the tongue, tonsil, esophagus, and urinary bladder; ovarian thecal cells
; fibroblasts of many tissues; fibroblastic reticular cells of the lymph nodes and tonsils; and the fibroblastic reticulum of the liver and adrenal cortex (Figure 1).
The granulosa cells are either columnar or cuboidal and are arranged in a regular manner together with thecal cells
It was non encapsulated proliferation of thecal cells
in the wall of atretic follicle and had all the pathological findings of late pregnancy luteoma (5).