They have shown that ERK1/2 phosphorylation is decreased in PCOS
theca cells compared to normal
theca cells and that CYP17 mRNA and androgen synthesis are increased in PCOS
theca cells.
After incubation, the
theca cells were stored at -20[degrees]C.
This study demonstrates a reduction in inhibin-[beta]A expression during the transition of primary follicles to the secondary stage, and its increase in mural granulosa /
theca cell complexes during the development of antral follicles.
It was demonstrated by Knight and Glister that growing oocytes, granulosa cells (GCs), a basement membrane, and
theca cells (TCs), as well as blood capillaries, are involved in the process of follicle-oocyte crosstalk that includes small metabolite transition [2].
Rare
theca cells were seen scattered in between the neoplastic granulosa cells.
Immunolocalization of [alpha]-TNF: Considering the importance of the expression of TNF-[alpha] in stimulating, proliferation and steroidogenesis in the ovarian follicle
theca cells, this study examined the expression levels of TNF-[alpha], in pre-antral and antral follicles which were observed in the granulosa layer in PCOS ovaries.
The increased LH successively promotes
theca cell androgens production, while the relative FSH deficiency interferes with granulosa cell aromatization to estrogens and impairs follicle maturation and ovulation (7).
3Rd, Guffey TA, Malkasian GD et al: Clinicopathologic review of 118 granulosa and 82
theca cell tumours.
In parallel with other assessments in this study, steroid hormones (E2 and P4) were used as a marker of granulosa and
theca cell function and data showed the steroidogenic pathways were present and increased during the in vitro culture of ovarian tissue in the presence of BMP15 and FSH.
Evidence for direct effects of glyphosate on ovarian function: Glyphosate influences steroidogenesis and proliferation of bovine granulosa but not
theca cells in vitro.
(9,) (12,) (31) The IGF-1 is a growth hormone that stimulates GC proliferation by regulating DNA replication in
theca cells and GCs.
Zona radiate were irregular in appearance,
theca cells were slightly enlarged and basal membrane disintegrated (Fig.
