Thalassemias


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Thalassemias

The name for a group of inherited disorders resulting from an imbalance in the production of one of the four chains of amino acids that make up hemoglobin. Thalassemias are categorized according to the amino acid chain affected. The two main types are alpha-thalassemia and betathalassemia. The disorders are further characterized by the presence of one defective gene (thalassemia minor) or two defective genes (thalassemia major). Symptoms vary, but include anemia, jaundice, skin ulcers, gallstones, and an enlarged spleen.
References in periodicals archive ?
Key Words: Thalassemia major, Hypocalcemia, Hypothyroid, Short stature, Diabetes mellitus
Knowledge Gaps/Research Problems: Fatimid Foundation is the largest organization in Khyber Pakhtunkhwa Province and also in Pakistan, proving blood, blood components and other related services to thalassemia patients.
In routine laboratory practice, the diagnosis of beta thalassemia trait is usually made by characteristic findings in the hemoglobin evaluation and the red blood cell count and indices.
The national thalassemia screening program for prevention of [beta]-thal major in Iran was initiated based on pre-marital screening since 1997 because of the high prevalence of [beta]-thalassemia.
Methods: This descriptive study females of child bearing age visiting FMH OPD presenting with hypochromic microcytic anemia were selected by non-probability purposive sampling and screened for beta thalassemia trait.
The automated cell counter-based parameters provide an excellent hematological data and continue to play a crucial role for screening and differentiation of all forms of thalassemias such as [alpha]-thalassemia traits, homozygous [alpha]-thalassemia, and [beta]-thalassemia major and minor.
Objectives: To devise a strategy for prevention of beta thalassemia in newborns through reliable screening of indexed families.
PESHAWAR -- Thalassemia Control Program observe World Thalassamia Day on Thursday here at Peshawar Press ClubTalking a news press conference Hamza Foundation Chairman Ijaz Khan said that still Thalassemia Bill 210 was not implemented in the province and demanded the government to implement the bill.
The thalassemias are classified by a decrease or absent production of a specific globulin chain.
I congratulate the authors for exploring at the molecular level at least one of the thalassemia minima that fits well with the present clinical thalassemia nomenclature.
Thalassemias. In: John Lilley man, Jan Hann and victor Blanchette.
Hemoglobinopathies and thalassemias are both hematologic diseases involving mutations in the genes that control the synthesis of globin chains that compose hemoglobin.