In atopic individuals, presentation of an antigen by DCs directs development of the Th cell
towards the Th2 subtype, whereas in non-atopic people the Th1 subtype is more likely to occur.
The supernatants were collected to check the cytokine levels for confirming the Th cell
Also, an imbalance in the relative numbers or/and activity of these Th cell
subpopulations may affect the state and progression of several diseases, including infectious, allergic and auto-immune disorders, but also cancer (Clerici et al.
Each Treg has a gene turned on that is also turned on in the corresponding Th cell
, and each Treg appears to be produced in greater numbers when its corresponding Th cell
responds to an intruder.
Differentiation of appropriate Th cell
subsets is critical to the protective immune response.
Mature Th cells
express the surface protein CD4 and are referred to as CD4+ T cells.
Human Immunodeficiency Virus (HIV-1) infection results in the gradual loss of TH cells
, decreased immune competence, and increased susceptibility to various opportunistic infections, including Pneumocystis jirovecii pneumonia, tuberculosis, and cytomegalovirus.
It also suppresses differentiation of Type 1 Th cells
, and promotes production of Type 2 Th cells
Upon antigenic stimulation, Th cells
differentiate into Th1 and Th2 subsets, which are characterized by the release of distinct cytokines profile.
After activation of naive ('Th0') cells, Th cells
can be distinguished by their cytokine profile.
The presentation, entitled "Recent Advances in Understanding the Immune System and the Role of Th cells
," will be given Wednesday, February 29 at 9:45 am EST.
Under normal conditions, CTLs recognize and attack diseased or virally infected cells with the help of TH cells