VLAIO's subsidy was granted to Argenx through its Innovative Access Programme (IAP) as funding of research around selective SIMPLE Antibody inhibition of TGF-beta
for potential therapeutic use in immuno-oncology.
Miscommunication resulted in TGF-beta
not being tested until after the lowering agents were in place, and it was not elevated.
Cell biologists review the current understanding of the biology of the TGF-beta
family of secreted differentiation factors, in papers that were first published online in Cold Spring Harbor Perspectives with the intention of publishing them in this volume once the research project was completed.
Interestingly, a broad subset of pancreatic cancers (PDAs) are characterized by high TGF-beta
superfamily ligands (TGFB_SLs) levels (TGF1, Nodal and Activin) and by prominent TGF-beta
signaling in tumor stromal cells.
signals regulate axonal development through distinct Smad-independent mechanisms.
The results make a strong case for TGF-beta
as playing a pivotal role in the pathogenesis of systemic sclerosis, according to Dr.
KLF2 suppresses TGF-beta
signaling in endothelium through induction of Smad7 and inhibition of AP-1," Arteriosclerosis, Thrombosis, and Vascular Biology, vol.
Leto, "Nox4 involvement in TGF-beta
and SMAD3driven induction of the epithelial-to-mesenchymal transition and migration of breast epithelial cells," Free Radical Biology and Medicine, vol.
Apoptosis in podocytes induced by TGF-beta
Researchers at Karolinska Institutet show that the signal molecule TGF-beta
acts as a time signal that regulates the nerve stem cells' potential at different stages of the brain's development, knowledge that may be significant for future pharmaceutical development.
Evidence for a role of transforming growth factor (TGF)-betal in the induction of postglomerular albuminuria in diabetic nephropathy: amelioration by soluble TGF-beta
type II receptor.
In their first test, the researchers found that stem cells changed into cartilage or bone cells in the directions of two opposing soluble growth factor gradients: one that promotes cartilage, called TGF-beta
1, and another that promotes bone, called BMP-2.