tetrodotoxin

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tetrodotoxin

 [tet´ro-do-tok″sin]
a highly lethal neurotoxin present in numerous species of puffer fish and in newts of the genus Taricha (in the latter it is called tarichatoxin); ingestion results in tetrodotoxism.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

tet·ro·do·tox·in (TTX),

(tet'rō-dō-tok'sin),
A potent neurotoxin found in the liver and ovaries of the Japanese pufferfish, Sphoeroides rubripes, other species of pufferfish, and some newts; produces axonal blocks of the preganglionic cholinergic fibers and the somatic motor nerves. Tetrodotoxin blocks voltage-gated Na+ channels in excitable tissues.
Farlex Partner Medical Dictionary © Farlex 2012

tetrodotoxin

(tĕ-trō′də-tŏk′sĭn)
n.
A potent neurotoxin, C11H17N3O8, found in many pufferfishes and certain other animals, including some salamanders and crabs.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

tetrodotoxin

A potent, heat-stable neurotoxin concentrated in certain tissues—liver, gonads, intestines and skin of fishes of order Tetraodontoidea (ocean sunfish, porcupine fish, and pufferfish/fugu); it is also present in lethal amounts in the California newt and eastern salamander.
 
Mechanism of action
Tetrodotoxin blocks conduction of sodium across membranes and neural transmission in skeletal muscle, and kills up to 60% of those who ingest it.
 
Clinical findings
Paraesthaesias begin 10-45 minute after ingestion, commonly as intraoral and tongue tingling; often associated with nausea, vomiting, light-headedness, vertigo, a sense of doom, weakness, hypersalivation, muscle twitching, diaphoresis, pleuritic chest pain, dysphagia, aphonia, convulsions, hypotension, bradycardia, depressed corneal reflexes, fixed dilated pupils.
 
Management
IV hydration, gastric lavage, activated charcoal.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

tetrodotoxin

Toxicology A potent heat-stable neurotoxin concentrated in fishes of order Tetraodontoidea; tetrodotoxin blocks conduction of sodium across membranes, and neural transmission in skeletal muscle, and kills up to 60% of those who ingest it, causing 50 deaths/yr in Japan Clinical Paresthesias begin 10-45 mins after ingestion, commonly as intraoral and tongue tingling, often associated with N&V, lightheadedness, vertigo, feelings of doom, weakness, hypersalivation, muscle twitching, diaphoresis, pleuritic chest pain, dysphagia, aphonia, convulsions, hypotension, bradycardia, depressed corneal reflexes, and fixed dilated pupils Management IV hydration, gastric lavage, activated charcoal
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

tetrodotoxin

Puffer fish toxin, one of the most powerful known neurotoxins with a mortality of about 50%. There is no known antidote.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005