tetrahydrolipstatin


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Related to tetrahydrolipstatin: Orlistat

tetrahydrolipstatin

An early anti-obesity pill of the class that acts by preventing the absorption of dietary fats. Experience has shown the disadvantages of this seemingly ideal way to enjoy the best of both worlds-abdominal discomfort, loss of fat-soluble vitamins, loss of advantageous fats such as fish oils, fatty stools hard to flush, and loss of the incentive to try to control greediness.
References in periodicals archive ?
It is possible to add nonabsorbable lipid to the lumen of the intestine, either as a dietary additive such as olestra or through the inhibition of lipase by a lipase inhibitor such as tetrahydrolipstatin. Established risks associated with either regimen are thus far limited to reductions in absorption of fat-soluble vitamins and loose stools which can often be moderated by the adjustment of dose.
The lipase inhibitor tetrahydrolipstatin binds covalently to the putative active site serine of pancreatic lipase.
Identification of the active-site serine in human pancreatic lipase by chemical modification with tetrahydrolipstatin. FEBS Lett.
Initial studies in humans with the novel gastrointestinal lipase inhibitor Ro 18-0647 (tetrahydrolipstatin).
Prevention of in vivo lipolysis by tetrahydrolipstatin. Clin Chem 2000;46:950-8.
[4] Nonstandard abbreviations: FFA, free fatty acid; HD, hemodialysis; UFH, unfractionated heparin; LMWH, low-molecular weight heparin; and THL, tetrahydrolipstatin.
More recently, tetrahydrolipstatin (THL; Orlistat[R]) was identified as a nontoxic, active-site inhibitor of mammalian lipases, including LPL (17), which could be used to effectively decrease lipolytic activity in plasma (18).
Interactions of lipoprotein lipase with the active-site inhibitor tetrahydrolipstatin (Orlistat).
Inhibition of lipoprotein lipase activity by tetrahydrolipstatin. Biochem Soc Trans 1997;25:S682.
Behavior of tetrahydrolipstatin in biological model membranes and emulsions.