CBs are prepared by mechanically shaping the wet hydrolyzed cellulose fibre fragments into spherical particles through spheronization and then loaded with model drugs such as isosorbide dinitrate, terodiline
, and N-actyl-L-cysteine for subsequent drug release studies [8, 9].
The rest of the drugs to trigger TdP were anti arrhythmic agents (n=6), psychotropic agents (n=4), anti-histamines (n=3) and terodiline (n=3) (Table 3).
Torsades de pointes ventricular tachycardia and terodiline. Lancet 1991; 338: 344-5.
The precedent for the intensive study of the cardiac effects of this drug class was terodiline, an antimuscarinic agent once used as a treatment for OAB.
Terodiline causes polymorphic ventricular tachycardia due to reduced heart rate and prolongation of QT interval.
(8) Nine noncardiac medications were affected, including terfenadine, astemizole, grepafloxicin, terodiline
, droperidol, lidoflazine, sertindole, levomethadyl, and cisapride.
The majority of cases (88%) were taking one or more prescribed drugs but only 2% were taking drugs to manage incontinence, these being oxybutynin and terodiline
. However, 40% of cases were taking diuretics, of whom two-thirds were using the powerful loop diuretics, frusemide and bumetanide.
On April 17, 1990, the WSJ carried news of two new drugs to help incontinent patients - terodiline
, licensed by Forest Laboratories, and DDAVP, sold by Rorer Group.
Effects of Terodiline
on urinary incontinence among older non-institutionalized women.
A trial of terodiline with bladder retraining was reported from this centre and failed to show any benefit over placebo .
A previous study, using a similar protocol to test the drug terodiline, failed to demonstrate such benefit.
It is our impression that UOB is also less responsive to emepromium bromide and terodiline
than is PDI.