termination factor


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re·leas·ing fac·tors (RF),

1. any substance, usually of hypothalamic origin, capable of accelerating the rate of secretion of a given hormone by the anterior pituitary gland;
2. factors required in the termination phase of either RNA biosynthesis or protein biosynthesis. Synonym(s): termination factor
3. colloquial shortened form for the HMG-CoA reductase inhibitors used as antihyperlipidemic agents, whose generic names end with the suffix statin. Synonym(s): statins

termination factor

one of a group of special proteins that mediates termination of protein synthesis by recognizing a TERMINATION CODON in mRNA and bringing about the release of the ribosomal subunits. Also called release factor (RF). see TRANSLATION.
References in periodicals archive ?
Topics include reconstruction of glutamine synthetase using computer averaging, a cryo-electron microscopic study of ribosome-bound termination factor RF2, the process of mRNA-tRNA translocation, and the structural basis for gating and activation of RyR1.
Cleavage of TAR by Microprocessor has major consequences 1) it provides a substrate for Rrp6, which generates a small RNA that represses HIV-1 transcription, 2) it creates an entry site for Xrn2 and termination factors that lead to premature termination of transcription.
"Are R&D Project Termination Factors Universal?" Research * Technology Management, July-Aug., 1995, pp.

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