In the lung, epithelial hyperplasia with squqmous metaplasia were noticed in the terminal bronchioles
Histopathologic Features of Chronic Obstructive Pulmonary Disease Emphysema Proximal acinar emphysema * Destruction of respiratory bronchioles with relative sparing of distal alveoli Panacinar emphysema * Destruction of respiratory bronchioles through to terminal alveoli Alteration of Respiratory (smoker's) bronchiolitis the airways Inflammation and fibrosis of terminal and respiratory bronchioles Reduction in terminal bronchioles
Goblet cell metaplasia Squamous metaplasia Alteration of Intimal thickening with smooth muscle the vasculature proliferation and elastin/collagen deposition Smooth muscle hyperplasia of the media
According to ELHAFEZ (2012), the canalicular stage is an important step in the development of the rabbit lung, since the terminal bronchioles
branches into 2-4 acinar channels, from which some cells of the epithelium line these channels and differentiate into type I pneumocytes.
Result: Structural changes were found in the experimental (5-fluorouracil) group compared to the controls, including abnormal alveolar duct, sac, and terminal bronchioles
with emphysematous changes in most of the alveoli in addition to peribronchiolitis, perivasculitis, inflammatory cells infiltration and interstitial fibrosis.
3] Histologically, CCAM are benign hamartomatous or dysplastic lung tumor, showing adenomatous overgrowth of terminal bronchioles
with reduction in alveoli.
The inflammatory response associated with MWCNT exposure was characterized by neutrophilia as determined by BALF cell differentials (Figure 4B) and by using immunohistochemical staining with an anti-neutrophil antibody, which revealed neutrophils near terminal bronchioles
and in proximity to macrophages containing O-MWCNTs (Figure 4C).
Congenital cystic adenomatoid malformation is an embrionic developmental disorder characterized by cystic enlargement and overgrowth of terminal bronchioles
which are surrounded by various epithelial cells.
The researchers also used microCT to measure the number and cross-sectional area of the small terminal bronchioles
, and performed histologic analysis to count the number of small airways per square centimeter and to measure the thickness of airway walls.
carcinogenesis) or some forms of developmental damage to the fetus (More serious inflammation: more toxic agents and/or higher exposures may be associated with damage resulting in inflammation for example of terminal bronchioles
and alveoli leading to a chemical pneumonitis and pulmonary oedema (e.
the terminal bronchioles
, alveolar ducts, and alveolar sacs.
The most frequent lung lesion cases are cellular-looping enhancement of the lung pattern due to sclerosis (infiltration, fibrosis) of interstitial tissue, apparition of small focused changes in the interstitial tissue and in the terminal bronchioles
, in small blood vessels, the shadowing focuses in the lung fields and "frosted glass" zones.
First, a clear topographic extension of the lesions was perceptible between the first and the last day of infection, with centrifugal spreading from the terminal bronchioles
or the alveoli adjacent to the airways.