Tenormin


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Related to Tenormin: atenolol

Tenormin

 [ten´or-min]
trademark for preparations of atenolol, a beta-adrenergic blocking agent used in treatment of hypertension, angina, and myocardial infarction.

atenolol

Antipressan (UK), Atenix (UK), Novo-Atenol (CA), Tenormin

Pharmacologic class: Beta-adrenergic blocker (selective)

Therapeutic class: Antianginal, anti-hypertensive

Pregnancy risk category D

FDA Box Warning

• Caution patients with coronary artery disease (CAD) not to discontinue drug abruptly, because this may cause severe angina exacerbation, myocardial infarction, and ventricular arrhythmias. (The last two complications may occur with or without preceding angina exacerbation.) With planned drug discontinuation, observe patients carefully and advise them to minimize physical activity; if angina worsens or acute coronary insufficiency develops, drug should be reinstituted promptly, at least temporarily. Because CAD is common and may go unrecognized, abrupt withdrawal may pose a risk even in patients treated only for hypertension.

Action

Selectively blocks beta1-adrenergic (myocardial) receptors; decreases cardiac output, peripheral resistance, and myocardial oxygen consumption. Also depresses renin secretion without affecting beta2-adrenergic (pulmonary, vascular, uterine) receptors.

Availability

Tablets: 25 mg, 50 mg, 100 mg

Indications and dosages

Hypertension

Adults: Initially, 50 mg P.O. once daily, increased to 100 mg after 7 to 14 days if needed

Angina pectoris

Adults: Initially, 50 mg P.O. once daily, increased to 100 mg after 7 days if needed. Some patients may require up to 200 mg daily.

Acute myocardial infarction

Adults: 50 mg tablet P.O., then give 50 mg P.O. in 12 hours. Maintenance dosage is 100 mg P.O. daily or 50 mg b.i.d. for 6 to 9 days.

Dosage adjustment

• Renal impairment

• Elderly patients

Contraindications

• Cardiogenic shock

• Sinus bradycardia

• Greater than first-degree heart block

• Heart failure (unless secondary to tachyarrhythmia treatable with beta-adrenergic blockers)

Precautions

Use cautiously in:

• renal failure, hepatic impairment, pulmonary disease, diabetes mellitus, thyrotoxicosis

• pregnant or breastfeeding patients

• children.

Administration

Adjust initial and subsequent dosages downward depending on clinical observations, including pulse rate and blood pressure.

Don't discontinue drug suddenly. Instead, taper dosage over 2 weeks.

Adverse reactions

CNS: fatigue, lethargy, vertigo, drowsiness, dizziness, depression, disorientation, short-term memory loss

CV: hypertension, intermittent claudication, cold arms and legs, orthostatic hypotension, bradycardia, arrhythmias, heart failure, cardiogenic shock, myocardial reinfarction

EENT: blurred vision, dry eyes, eye irritation, conjunctivitis, stuffy nose, rhinitis, pharyngitis, laryngospasm

GI: nausea, vomiting, diarrhea, constipation, gastric pain, flatulence, anorexia, ischemic colitis, retroperitoneal fibrosis, acute pancreatitis, mesenteric arterial thrombosis

GU: impotence, decreased libido, dysuria, nocturia, Peyronie's disease, renal failure

Hematologic: agranulocytosis

Hepatic: hepatomegaly

Metabolic: hypoglycemia

Musculoskeletal: muscle cramps, back and joint pain

Respiratory: dyspnea, wheezing, respiratory distress, bronchospasm, bronchial obstruction, pulmonary emboli

Other: decreased exercise tolerance, allergic reaction, fever, development of antinuclear antibodies, hypersensitivity reaction

Interactions

Drug-drug. Amiodarone, cardiac glycosides, diltiazem, verapamil: increased myocardial depression, causing excessive bradycardia and heart block

Amphetamines, cocaine, ephedrine, norepinephrine, phenylephrine, pseudoephedrine: excessive hypertension, bradycardia

Ampicillin, calcium salts: decreased antihypertensive and antianginal effects

Aspirin, bismuth subsalicylate, magnesium salicylate, nonsteroidal anti-inflammatory drugs: decreased anti-hypertensive effect

Clonidine: life-threatening blood pressure increase after clonidine withdrawal or simultaneous withdrawal of both drugs

Dobutamine, dopamine: decrease in beneficial beta-cardiovascular effects

Lidocaine: increased lidocaine levels, greater risk of toxicity

MAO inhibitors: bradycardia Prazosin: increased risk of orthostatic hypotension

Reserpine: increased hypotension, marked bradycardia

Theophylline: decreased theophylline elimination

Drug-diagnostic tests. Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, antinuclear antibody titer, blood urea nitrogen, creatinine, lactate dehydrogenase, platelets, potassium, uric acid: increased levels

Glucose: increased or decreased level

Insulin tolerance test: false result

Drug-behaviors. Alcohol use: increased hypotension

Patient monitoring

• Watch for signs and symptoms of hypersensitivity reaction.

• Monitor vital signs (especially blood pressure), ECG, and exercise tolerance.

• Check closely for hypotension in hemodialysis patients.

• Monitor blood glucose level regularly if patient is diabetic; drug may mask signs and symptoms of hypoglycemia.

Patient teaching

Instruct patient to immediately report signs and symptoms of allergic response, breathing problems, and chest pain.

• Advise patient to take drug at same time every day.

Inform patient that he may experience serious reactions if he stops taking drug suddenly. Advise him to consult prescriber before discontinuing.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• Tell patient that drug may cause a temporary blood pressure decrease if he stands or sits up suddenly. Instruct him to rise slowly and carefully.

• Inform women that drug shouldn't be taken during pregnancy. Urge them to report planned or suspected pregnancy.

• Tell men that drug may cause erectile dysfunction. Advise them to discuss this issue with prescriber.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, and behaviors mentioned above.

Tenormin

(tə-nôr′mĭn)
A trademark for preparations of the drug atenolol.

Tenormin

a trademark for a beta-blocker (atenolol).

Tenormin®

Atenolol, see there.

Tenormin

A brand name for ATENOLOL.
References in periodicals archive ?
illustrates the following information: (i) Tenormin had already lost a great deal of its market share a year before the implementation of the law; (ii) Ten-Bloka is the market leader in providing Atenolol in the private sector, both before and after implementation of the law; (iii) the market share of Rolab-Atenolol remained low over the 2-year period examined; and (iv) visually, there appears to be a change in trend at the end of 2002.
Aldomet, Sytensin, Tenex, Catapres, Ismelin, Hylorel, reserpine, Inderal, Corgard, Tenormin, Blocadren, Lopressor, Visken, Normodyne/Trandate, Sectral, Levatol, Cartrol, Isoptin/Calan/Verelan, Kerlone
The most commonly used beta blockers include Inderal, Lopressor, and Tenormin.
Other tests showed juices can affect the absorption of anti-cancer drugs such as etoposide (Etopophos, Vepesid), beta blockers such as tenormin (Atenolol) and talinolol (Cordanum), and antibiotics such as ciprofloxacin (Cipro), levofloxacin (Levaquin) and itraconazole (Sporanox).
He is on Neurontin for restless legs syndrome and on Tenormin, Accupril, and hydrochlorothiazide for high blood pressure.
Cardiovascular products like Inderal and Tenormin were leader in pharma sale.
Atenolol * Tenormin Bupropion * Wellbutrin Citalopram * Celexa Escitalopram * Lexapro Fluoxetine * Prozac Hydrochlorothiazide * Esidrix, HydroDIURIL, 0retic Mirtazapine * Remeron Paroxetine * Paxil Sertraline * Zoloff Venlafaxine * Effexor
Atenolol, sold under the brand name Tenormin (AstraZeneca Pharmaceuticals LP), is a beta blocker.
Blood pressure drugs Beta blockers: Lopressor, Tenormin, Toprol
Wellspring, which is offered free to patients who are prescribed ICI's Tenormin (atenolol), aims to improve compliance by communicating important information about high blood pressure and its treatment, and encouraging the adoption of healthier lifestyles.
Brand Name Drugs Equivalent Commonly GenericSelect Drug Brand Other Brands Used For Fluoxetine(a) Prozac Celexa, Lexapro(a), Depression Paxil CR(a), Zoloft(a) Lovastatin(a) Mevacor Crestor, Lescol, High Lipitor(a), Cholesterol Pravachol(a), Zocor Ranitidine Tablets(a) Zantac AcipHex(a), Acid Tablets Nexium, Reflux Prevacid(a), Protonix, Prilosec Lisinopril(a) Zestril, Avapro, Hypertension Prinivil Atacand, Benicar, Cozaar(a), Diovan(a), Atenolol(a) Tenormin Micardis, Norvasc(a), Teveten Metoprolol(a) Lopressor Chlorthalidone Hygroton Hydrochlorothiazide(a) Oretic Metformin(a) Glucophage Actos(a), Diabetes Avandia(a) Glyburide(a) Micronase, Diabeta Glipizide(a) Glucotrol Ibuprofen(a) Motrin Bextra, Celebrex, Arthritis Vioxx Pain Naproxen(a) Naprosyn (a) Formulary drug