temozolomide

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temozolomide

 [tem″ah-zo´lah-mīd]
a cytotoxic alkylating agent used as an antineoplastic in the treatment of refractory anaplastic astrocytoma, administered orally.

temozolomide

/tem·o·zo·lo·mide/ (tem″ah-zo´lah-mīd) a cytotoxic alkylating agent used as an antineoplastic in the treatment of refractory anaplastic astrocytoma.

temozolomide

a miscellaneous antineoplastic agent.
indication It is used to treat anaplastic astrocytoma with relapse.
contraindications Pregnancy, lactation, and known hypersensitivity to this drug or to carbazine prohibit its use.
adverse effects Life-threatening effects are thrombocytopenia, leukopenia, and seizures. Other adverse effects include anemia, urinary incontinence, urinary tract infection, urinary frequency, upper respiratory infection, pharyngitis, sinusitis, cough, headache, fatigue, asthenia, fever, edema, back pain, weight increase, and diplopia. Common side effects include nausea, anorexia, vomiting, hemiparesis, dizziness, poor coordination, amnesia, insomnia, paresthesia, somnolence, paresis, ataxia, anxiety, dysphagia, depression, confusion, rash, and pruritus.

temozolomide

Temodal® Oncology An alkylating agent used for recurrent gliomas–eg, anaplastic astrocytoma, and possibly melanoma and other solid tumors. See Astrocytoma, Glioblastoma multiforme.
References in periodicals archive ?
Temodal was developed by Cancer Research Campaign scientists.
Figures released today showed that sales of Temodal have delivered more than pounds 1m in royalties to the Cancer Research Campaign, whose scientists developed the drug.
Figures released yesterday showed that sales of Temodal over the past two years have delivered more than pounds 1m in royalties to the Cancer Research Campaign, whose scientists developed the drug.
Figures released today show sales of Temodal over the last two years have delivered more than pounds 1 million in royalties to the Cancer Research Campaign, whose scientists developed the drug.
Temodal is by far the most effective drug for brain cancer but drug companies can't be bothered going round all these trusts to negotiate.
Developed by the Cancer Research Campaign, it will be available on the NHS next month - marketed as Temodal.
In trials, temozolomide - to be marketed as Temodal in a deal aimed to bring substantial royalties to the cancer group - boosted survival rates and reduced debilitating side effects.
In the life and health sciences' vision science group we have Britain's only whole-head MEG Brain Scanner, which is a national resource, while pharmacy has recently seen the launch of the new cancer drug, Temodal, originally developed at Aston.
We also focused on taxol (ovarian cancer), taxotere (breast cancer), irinotecan (bowel cancer), temodal (brain cancer), rilutek (motor neurone disease), beta interferon (multiple sclerosis) and aricept (Alzheimer's).
Marketed drugs include Temozolomide (also known as Temodal, Temodar and Temcad), a drug discovered by Cancer Research UK scientists, that is an effective new treatment for brain cancer and Abiraterone Acetate (also known as Zytiga) which was co-discovered by Cancer Research UK scientists to treat advanced prostate cancer.
TEMODAL is currently marketed in Canada for the treatment of recurrent or progressive GBM or anaplastic astrocytoma (AA), another form of brain tumor.