Neither does he tell us about the medicines that contained organic fluoride compounds which have been withdrawn due to safety concerns - Tolrestat, withdrawn in 1997 amid concerns about severe liver toxicity, and the antibiotic Temafloxacin
withdrawn in 1992 after amid concerns over deaths and liver dysfunction.
In United States, Gatifloxacin was voluntarily withdrawn from the market by the manufacturer in 2006 , just as temafloxacin and clinafloxacin were withdrawn in the 1990s, due to numerous adverse drug events, including hypoglycaemia .
 found that levofloxacin, gatifloxacin, and temafloxacin inhibit the Kir6.2 subunits of pancreatic [beta]-cells.
(14) Examples of international drug withdrawals have included fulminant liver failure with troglitazone, QT prolongation and ventricular arrhythmias with cisapride, haemolytic anaemia, coagulopathy and renal or hepatic dysfunction with temafloxacin
, and fatal rhabdomyolysis with cerivastatin.
Gatifloxacin and temafloxacin
have greater affinity, and thus greater hypoglycemic effect than other fluoroquinolones such as ciprofloxacin and levofloxacin.
Serious adverse drug effects in patients led to the withdrawal or restriction of four quinolones in the past decade (temafloxacin
, grepafloxacin, trovafloxacin, and sparfloxacin).
Perrone, C., Gikas, A, Truffot-Penot C., et al.: Activities of Sparfloxacin, Azithromycin, Temafloxacin
, and Rifapentine Compared with That of Clarithromycin Against Multiplication of Mycobacterium Avium Complex Within Human Macrophages.
The antibiotic (which is generically referred to as temafloxacin
) could bring in hundreds of millions of dollars in annual sales for the company that is best known for its diagnostic equipment, hospital supplies and nutritional products.
(1) These studies show that the coadministration of antibiotics (ampicillin, tetracycline, doxycycline, metronidazole, erythromycin, clarithromycin, temafloxacin
, fluconazole, ciprofloxacin, or ofloxacin) did not reduce serum levels of either the estrogen or progestin components of the oral contraceptives.
Although some members of the class (temafloxacin
, grepafloxacin, and trovafloxacin) have been withdrawn or restricted because of adverse events, new members continue to be developed and approved (gatifloxacin and moxifloxacin).
Because of several reports of severe reactions to temafloxacin
, it is no longer available. Crystalluria has been reported in patients with alkaline urine, but this problem can be avoided by maintaining adequate hydration and urine acidity.